Efficient logistics management requires the development of advanced tools to streamline delivery operations. This study aims to optimize vehicle routes for an animal feed store and develop a web-based application for route planning. The research compares two optimization methods: the Branch and Bound Method and Clustering with the Branch and Bound Method. These methods are evaluated against the store’s existing delivery route by analyzing differences in average travel distance across three dependent groups using Repeated Measures ANOVA. The findings reveal a statistically significant difference in average daily travel distances among the three methods at a 0.05 significance level. The Branch and Bound Method yields the shortest average daily travel distance. Additionally, pairwise comparisons of total daily travel distances using the Paired t-test confirm that the Branch and Bound Method produces the most efficient route with statistical significance at 0.05 level. Implementing this method can reduce total travel distance by 957.51, representing a 30.88% reduction, which translates into fuel cost savings of 2,579.45 THB per month. Based on these results, the Branch and Bound Method was selected for implementation in a web-based application. The application features an intuitive user interface, product inventory management, and optimized daily delivery route recommendations for the case study store. Following development, the web application was deployed and tested in real-world operations. The results demonstrate that it effectively provides map-based route recommendations, ensuring ease of use and accessibility on standard mobile devices.