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Toys Design from Scrap Wood Waste by Pallet Maker Group Co., Ltd.

Abstract

Toys Design from Scrap Wood Waste by Pallet Maker Group Co., Ltd.

Objective

บริษัท พาเลท เมกเกอร์ กรุ๊ป จำกัด เป็นผู้ผลิตพาเลทไม้ ซึ่งมีกระบวนการผลิตที่ทำให้เกิดเศษไม้เหลือทิ้งจำนวนมาก เศษไม้เหล่านี้มักถูกกำจัดทิ้งหรือนำไปขายในราคาต่ำ ซึ่งนอกจากจะเป็นการสูญเสียทรัพยากรแล้วยังส่งผลกระทบต่อสิ่งแวดล้อม เช่น การเพิ่มปริมาณขยะและปัญหาการตัดไม้ทำลายป่า โครงการนี้จึงมีแนวคิดในการนำเศษไม้เหล่านี้มาออกแบบและผลิตเป็นของเล่นเชิงการศึกษาที่ช่วยเสริมสร้างพัฒนาการของเด็ก โดยมุ่งเน้นให้เป็นของเล่นที่ปลอดภัยและเป็นมิตรต่อสิ่งแวดล้อม นอกจากนี้ โครงการนี้ยังสอดคล้องกับแนวคิดเศรษฐกิจหมุนเวียน (Circular Economy) ที่มุ่งเน้นการใช้ทรัพยากรอย่างคุ้มค่าและลดขยะ ด้วยการนำวัสดุเหลือใช้กลับมาใช้ใหม่ (Upcycling) อีกทั้งยังแสดงให้เห็นถึงความสำคัญของการออกแบบอย่างรับผิดชอบ ที่สามารถสร้างมูลค่าเพิ่มจากวัสดุที่ถูกมองข้ามได้อย่างสร้างสรรค์

Other Innovations

Decoding the Impact of RGL3 Genetic Variants on Protein Structure and Binding Site: A Bioinformatics Approach to Uncover Potential Hypertension Associations

คณะแพทยศาสตร์

Decoding the Impact of RGL3 Genetic Variants on Protein Structure and Binding Site: A Bioinformatics Approach to Uncover Potential Hypertension Associations

Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.

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Enhancing the efficiency of in-ear monitors for hearing-impaired musicians

วิทยาลัยวิศวกรรมสังคีต

Enhancing the efficiency of in-ear monitors for hearing-impaired musicians

Some musicians are hearing impaired, some have finished their careers, but some continue to work, and it is much harder for them to be deaf than for musicians who are not. Some use hearing aids in their daily lives and use in-ear monitors in their live performances, which seem normal, but in their in-ears they only hear the metronome and drums. How can we improve the performance of in-ear monitors to near normal?

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Niyom Thai

คณะศิลปศาสตร์

Niyom Thai

"Niyom Thai" represents health-centric footwear adorned with traditional Thai patterns, embodying an innovative approach to sustainable development tailored to the current needs of local communities. These shoes utilize natural materials to mitigate fatigue and integrate safety technologies, including location tracking via a mobile application and heart rate monitoring. This addresses the aspects of convenience and well-being in both daily life and travel

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