Toys Design from Scrap Wood Waste by Pallet Maker Group Co., Ltd.
บริษัท พาเลท เมกเกอร์ กรุ๊ป จำกัด เป็นผู้ผลิตพาเลทไม้ ซึ่งมีกระบวนการผลิตที่ทำให้เกิดเศษไม้เหลือทิ้งจำนวนมาก เศษไม้เหล่านี้มักถูกกำจัดทิ้งหรือนำไปขายในราคาต่ำ ซึ่งนอกจากจะเป็นการสูญเสียทรัพยากรแล้วยังส่งผลกระทบต่อสิ่งแวดล้อม เช่น การเพิ่มปริมาณขยะและปัญหาการตัดไม้ทำลายป่า โครงการนี้จึงมีแนวคิดในการนำเศษไม้เหล่านี้มาออกแบบและผลิตเป็นของเล่นเชิงการศึกษาที่ช่วยเสริมสร้างพัฒนาการของเด็ก โดยมุ่งเน้นให้เป็นของเล่นที่ปลอดภัยและเป็นมิตรต่อสิ่งแวดล้อม นอกจากนี้ โครงการนี้ยังสอดคล้องกับแนวคิดเศรษฐกิจหมุนเวียน (Circular Economy) ที่มุ่งเน้นการใช้ทรัพยากรอย่างคุ้มค่าและลดขยะ ด้วยการนำวัสดุเหลือใช้กลับมาใช้ใหม่ (Upcycling) อีกทั้งยังแสดงให้เห็นถึงความสำคัญของการออกแบบอย่างรับผิดชอบ ที่สามารถสร้างมูลค่าเพิ่มจากวัสดุที่ถูกมองข้ามได้อย่างสร้างสรรค์
วิทยาลัยนวัตกรรมการผลิตขั้นสูง
Ultrasonic cleaning tank is a machine that many factories widely used to clean objects. At one factory, a problem occurred in the cleaning process, resulting in the factory not being able to clean objects, but cracks also appeared on some objects. It was anticipated that these were caused by uneven acoustics pressure distribution which resulted in unsuitable cavitation This directly affected cleaning performance within the tank. In order to improve the tank's efficacy, in this research, we use Harmonic Response Analysis in ANSYS simulate simulate the occurrence of acoustic pressure in the tank to find the appropriate conditions of factors affected the intensity and the distribution pattern of acoustic pressure in ultrasonic tank, including the position of object, power, ultrasonic frequency and a suitable type and placing position of the transducer for the tank. Reliability of the simulate results was validate by the actual result from the foil corrosion test and the ultrasonic power probe. We found that objects receive different pattern of corrosion at each location. When temperature increasing the intensity of cavitation was increased. When we increase the ultrasonic frequency, acoustic pressure that is evenly dispersed throughout the tank.
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
คณะสถาปัตยกรรม ศิลปะและการออกแบบ
In the world of blood donation, there are 2 types of people: those who donate blood and those who don't. Most campaigners emphasize how to persuade more people to donate blood and recruit more new blood donors. We believe that even though such focus is important, there're more critical aspects that might have been neglected, which is: for those who have already made up their minds to be blood doners, will they be successful in donating when the time comes? According to our studies, only 63 % of attempted doners are successful. Regrettably, 37 % has to go home disappointed as their bodies are not fit for the conditions required by Red Cross medical staff at blood donation centers (which include some most basic preparations such as low-fat food intake and 8-hours sleep on the night before). Our campaign, ‘Blood in Need, Buddy Indeed’, focuses on 2 aspects. Firstly, to persuade more people to donate blood. Secondly, for those who have made up their minds to donate blood, we will provide necessary support (both body and mind) so that they are fully prepared and successful in donating blood when the time comes via networks of systems, staffs and the newly designed and prototype of the application ‘Blood D’. Our campaign covers the whole ‘before/during/after’ experience of users (as blood doners). Support includes assessment of their current condition whether they are within the requirement of Red Cross Blood Bank. ‘Blood D’ will also provide relevant information on blood donating events, such as locations, and time booking. Once sign-up, the application “Blood D” will sent friendly reminder and clear infographic on how to prepare their bodies as daily notifications during the 7 days countdown. This is to ensure that the users’ blood will be ‘D’ (homophone of the Thai word ‘ดี’ which mean ‘good’ and at the same time playing on the word ‘ Buddy’) or be the ‘good blood’ that can save lives for those in need. After organizing 4 blood donation events both within and outside the KMITL. The numbers of successful blood doners have increased from 63 % to 78 % (this number is the average of 4 events, with the most successful event of 89%). The campaign has won the first runner up in national blood donation campaign competition. It is highly anticipated that once the application “Blood D” is fully launched, it will help increase the amount of blood collected up to 15% with the same numbers of existing doners.