Study on Parasites in Blackchin Tilapia and Value-Added Processing Parasites play a crucial role in affecting fish health and the balance of marine ecosystems. The study of parasites in fish is essential for assessing fish population status and their impact on the ecosystem. This research focuses on a preliminary survey of parasites in Blackchin Tilapia (Sarotherodon melanotheron) found in the waters of Chumphon Province to determine whether this species carries parasitic infections. The findings will provide valuable insights for managing marine resources and developing strategies for processing Blackchin Tilapia into food products to help control its population in the ecosystem. One of the value-added processing approaches for Blackchin Tilapia is the "Nai Hoi Hua Fu" product. This product involves deep-frying the fish to achieve a crispy and fluffy texture before mixing it with mango salad to enhance its flavor and make it more appealing. This processing method not only adds value to the fish but also serves as a practical solution for managing the Blackchin Tilapia population, which may impact the ecosystem. The study results indicate that no parasitic infections were found in either the internal or external organs of the sampled fish, suggesting that the marine environment in the study area is favorable for fish health. However, continuous research is recommended to monitor long-term ecological changes and evaluate the impact of Blackchin Tilapia on ecosystem balance to ensure sustainable resource management.
มีการแพร่ระบาดปลาหมอคางดำ ในพื้นที่จังหวัดชุมพร โดยเฉพาะปากแม่น้ำ ดังนั้น จึงมีความสนใจว่าปลาชนิดนี้แพร่กระจายลงสู่ทะเลหรือไม จึงสำรวจพร้มอศึกาาาการติดเชื้อปรสิต เนื่องจากอยากทราบว่าทำไมถึงแพร่กระจายในระบบนิเวศเร็วมาก และสามารถนำมารับประทานได้หรือไม่
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
คณะสถาปัตยกรรม ศิลปะและการออกแบบ
This piece represents the collection of all human elements, applied to design for maximum efficiency, following the principles of Modern designers who embraced the famous phrase "Form follows Function." Every line and structure of the design is carefully considered for user comfort and practical use, while reflecting the idea that the user's experience is central to the design process. The beauty emerges from the harmony between function and form, not only meeting functional needs but also enhancing the aesthetic of Modernist design in a complete and meaningful way.
คณะวิศวกรรมศาสตร์
Nowadays, consumers may have experienced situations where they don't know which product to use based on their skin problems, the product they use doesn't give the desired results, the product is not worth the price, allergic to certain chemicals in the product ,or use multiple products and have ingredients that should not be used together leading to irritation. For this reason, we develop an application to analyze skin care product ingredients to solve such problems. This allows consumers to correctly understand information about the ingredients in products and know which products they should use according to their skin problems without having to rely on chemical knowledge and get products that are the best value for money. The project has integrated software knowledge to develop an application for analyzing skin care product ingredients. To find and recommend suitable skin care products to consumers. The information on various important ingredients has been collected from reliable articles and research.