Siamese fighting fish (Betta splendens) is an ornamental fish that is the first exported economically valuable fish in the country, but there is a limitation to increase the production of betta fish due to climate variability and the shortage of Thai workers. This research aims to develop 2 systems: a betta fish fry nursery system and a market-sized betta fish rearing system by using automated technology to precisely control the water quality in the system and reduce labor costs. Using precise automation consists of two systems: a minimal-waste system, which repurposes some of the waste generated from farming, and a zero-waste system, which treats and recycles all wastewater from farming. These systems aim to address issues related to water quality, animal welfare, and labor requirements in Betta fish farming. Experimental results show that these systems improve Betta fish survival rates by 10-15% compared to traditional methods. When considering net returns, the zero- waste system provides the highest profitability.
ในการเพาะเลี้ยงปลากัดประกอบด้วย ระบบอนุบาลลูกปลากัด เป็นการเลี้ยงลูกปลากัดในบ่อปูนซีเมนต์ขนาดเส้นผ่านศูนย์กลาง 60-80 เซนติเมตร มีการเพิ่มระดับน้ำแทนการเปลี่ยนถ่ายน้ำสัปดาห์ละ 5-10 เซนติเมตรจากระดับน้ำเดิม และการเลี้ยงปลาขนาดตลาด เป็นการเลี้ยงปลากัดในขวดแบนเรียงต่อกันจำนวนมากบนพื้นคอนกรีต มีการให้อาหารหรือเปลี่ยนถ่ายน้ำโดยใช้แรงงานคน 1 คนต่อการเลี้ยงปลากัด 10,000 – 40,000 ตัว ดังนั้นระบบอนุบาลและการเลี้ยงปลากัดขนาดตลาดแบบพัฒนาใหม่โดยใช้เทคโนโลยีในการควบคุมคุณภาพน้ำ การให้อาหารและการเปลี่ยนถ่ายน้ำด้วยระบบอัตโนมัติ จะช่วยแก้ปัญหาอัตราการตายของปลา การใช้แรงงาน และยังสามารถเพิ่มอัตราการรอดของลูกปลากัดได้อีกด้วย
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
คณะเทคโนโลยีการเกษตร
Mangosteen peel (Garcinia mangostana Linn.) extract using hot water (MPE) has been shown to have antibacterial potential in freshwater sea bass (Lates calcarifer) larvae infected with Aeromonas hydrophila. In vitro studies showed that MPE has a minimum inhibitory concentration (MIC) of 25 ppm and a minimum bactericidal concentration (MBC) of 25 ppm. In vivo, sea bass larvae were immersed in various concentrations of MPE at 0 ppm (control), 20 ppm, 40 ppm and 60 ppm, respectively, for 7 days with A. hydrophila. The results showed that the MPE-treated group had a higher survival rate compared to the control group. Hematological parameters showed that the MPE-treated group had significantly increased red blood cell (RBC), white blood cell (WBC) and hemoglobin (Hb) concentrations compared to the control group. In addition, the water quality parameters were not significantly different, except for ammonia concentration, with MPE having an ammonia concentration of 60 ppm being the lowest. All results can indicate that MPE can improve the antibacterial potential and the culture potential of sea bass larvae.
วิทยาเขตชุมพรเขตรอุดมศักดิ์
This project aims to design and develop a propulsion system for agricultural equipment using RFID technology and evaluate its movement performance on different surfaces, including concrete and grass. The experiment focuses on examining the tag detection range under transmission power levels of 20 dBm, 23 dBm, and 26 dBm, as well as the impact of antenna angles on detection efficiency. Additionally, the system was tested in three movement scenarios: straight path, left turn, and right turn, at distances of 2 meters, 4 meters, and 6 meters. The results indicate that the system achieved the highest average speed of 0.4736 m/s and an average turning angle of 91.6° when moving in a straight path on a concrete surface at a distance of 4 meters. On a grass surface at the same distance, the average speed was 0.4483 m/s, with an average turning angle of 91.1°. For left and right turns, the movement on the concrete surface generally exhibited a higher average speed than on grass, particularly at a distance of 4 meters, where differences in turning angles were observed. This study provides insights into the factors affecting the movement of agricultural mowing equipment and serves as a foundation for enhancing the efficiency of propulsion systems in future developments.