A Photographic series that expresses the abstract states of myself, towards the question of existence that results from being surrounded by expectations of both surrender and freedom of expression, this series focuses on my own subjectivities in order to bring back memories of almost forgotten feelings and make them clear once more.
การที่เติบโตมาจากครอบครัวที่คาดหวังในตัวเรา ที่สมาชิกคาดหวังในตัวเราไม่เหมือนกัน ถ้าเราทำแบบใดแบบหนึ่งที่คนใดคนหนึ่งต้องการอีกคนจะไม่พอใจ จนเราเกิดสงสัยว่าเราต้องเป็นแบบไหน เมื่อเข้ามาอยู่ในสังคมใหม่ทำให้เราตั้งคำถามกับตนเองเมื่อเข้าหาผู้คนว่าเราต้องเป็นไปแบบที่เขาต้องการหรือเปล่าเราถึงจะเข้าถึงเขาได้ ทำให้เราสับสนกับตัวเองและต้องสร้างตัวตนใหม่ไปตามที่คนคนนั้นพอใจ จนเราเองเริ่มเกิดคำถามว่าจริงๆแล้วตัวตนของเราจริงๆเป็นแบบไหน
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
คณะวิศวกรรมศาสตร์
The evaluation of mango yield and consumer behavior reflects an increasing awareness of product origins, with a growing demand for traceability to understand how the produce has been cultivated and managed. This study explores the relationship between mango characteristics and cultivation practices before harvest, using location identification to provide insights into these processes. To achieve this, a model was developed to detect and locate mangoes using 2D images via a Deep Learning approach. The study also investigates techniques to determine the real-world coordinates of mangoes from 2D images. The YOLOv8 model was employed for object detection, integrated with camera calibration and triangulation techniques to estimate the 3D positions of detected mangoes. Experiments involved 125 trials with randomized mango positions and camera placements at varying yaw and pitch angles. Parameters extracted from sequential images were compared to derive the actual 3D positions of the mangoes. The YOLOv8 model demonstrated high performance with prediction metrics of Precision (0.928), Recall (0.901), mAP50 (0.965), mAP50-95 (0.785), and F1-Score (0.914). These results indicate sufficient accuracy for predicting mango positions, with an average positional error of approximately 38 centimeters.
วิทยาเขตชุมพรเขตรอุดมศักดิ์
This project aims to design and develop an eye-tracking system to facilitate communication for paralyzed immobile patients. The system is designed to enable patients to convey their needs to caregivers or family members by detecting and tracking eye movements using the Tobii Eye Tracker 5 device. This approach serves as an alternative communication method, replacing the physical movement or speech of paralyzed patients. The system effectively detects and tracks eye movements at a distance of 55 to 85 centimeters and is designed for installation on a computer to ensure ease of use. The program interface consists of three main sections: (1) a set of emotions, (2) a set of needs, and (3) a set of additional needs. It supports input from a virtual keyboard in both Thai and English and allows users to specify additional needs through eye-tracking-enabled typing. Furthermore, the system can generate synthetic speech for text that is difficult to pronounce aloud, send notification messages via the Line application, and store usage data in a database presented in a dashboard format. System testing revealed that the optimal detection distance ranges from 65 to 75 centimeters, as this range yields an error rate of no more than 1 percent. The system accurately responds to eye movements for communication through sound within 3 seconds when interacting with various function buttons. This eye-tracking system effectively enables paralyzed immobile patients to communicate their emotions and needs, facilitating better understanding and interaction between patients and their caregivers or family members.