A Photographic series that expresses the abstract states of myself, towards the question of existence that results from being surrounded by expectations of both surrender and freedom of expression, this series focuses on my own subjectivities in order to bring back memories of almost forgotten feelings and make them clear once more.
การที่เติบโตมาจากครอบครัวที่คาดหวังในตัวเรา ที่สมาชิกคาดหวังในตัวเราไม่เหมือนกัน ถ้าเราทำแบบใดแบบหนึ่งที่คนใดคนหนึ่งต้องการอีกคนจะไม่พอใจ จนเราเกิดสงสัยว่าเราต้องเป็นแบบไหน เมื่อเข้ามาอยู่ในสังคมใหม่ทำให้เราตั้งคำถามกับตนเองเมื่อเข้าหาผู้คนว่าเราต้องเป็นไปแบบที่เขาต้องการหรือเปล่าเราถึงจะเข้าถึงเขาได้ ทำให้เราสับสนกับตัวเองและต้องสร้างตัวตนใหม่ไปตามที่คนคนนั้นพอใจ จนเราเองเริ่มเกิดคำถามว่าจริงๆแล้วตัวตนของเราจริงๆเป็นแบบไหน
คณะสถาปัตยกรรม ศิลปะและการออกแบบ
Koh Tao, a picturesque island in Thailand, is famous for its breathtaking coral reefs and vibrant marine life, attracting diving enthusiasts from all over the world. Despite its natural beauty, the island currently lacks innovative accommodations that enhance the visitor experience and promote environmental sustainability. This project proposes the development of a unique four-star floating resort with underwater villas, designed to offer an extraordinary lodging experience that fosters a deeper connection with the marine environment. By incorporating sustainable practices into the resort's design and operations, the project addresses the growing demand for eco-friendly tourism in the region. The floating resort concept aims not only to provide guests with an immersive experience but also to raise awareness about marine conservation. Through eco-friendly design and operations, the resort seeks to set a benchmark for sustainable tourism in Koh Tao, showcasing how accommodations can align with environmental stewardship, benefiting both the local ecosystem and tourism.
คณะแพทยศาสตร์
Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.
คณะเทคโนโลยีการเกษตร
This study examines the effects of chemical mutagens, ethyl methane sulfonate (EMS) and colchicine in inducing mutations in Chrysanthemum spp. through tissue culture techniques. In vitro cultures of Chrysanthemum were treated with various concentrations of EMS and colchicine to assess their impact on shoot regeneration and mutation frequency. Results indicated that EMS significantly increased phenotypic variability, leading to enhanced flower color and size, while colchicine treatment effectively induced polyploidy, resulting in plants with greater flower size and overall vigor. Morphological assessments, along with genetic analyses using molecular markers, confirmed the mutations associated with these treatments. The integration of chemical mutagenesis with tissue culture presents a promising approach for developing novel Chrysanthemum varieties with improved ornamental traits.