A Photographic series that expresses the abstract states of myself, towards the question of existence that results from being surrounded by expectations of both surrender and freedom of expression, this series focuses on my own subjectivities in order to bring back memories of almost forgotten feelings and make them clear once more.
การที่เติบโตมาจากครอบครัวที่คาดหวังในตัวเรา ที่สมาชิกคาดหวังในตัวเราไม่เหมือนกัน ถ้าเราทำแบบใดแบบหนึ่งที่คนใดคนหนึ่งต้องการอีกคนจะไม่พอใจ จนเราเกิดสงสัยว่าเราต้องเป็นแบบไหน เมื่อเข้ามาอยู่ในสังคมใหม่ทำให้เราตั้งคำถามกับตนเองเมื่อเข้าหาผู้คนว่าเราต้องเป็นไปแบบที่เขาต้องการหรือเปล่าเราถึงจะเข้าถึงเขาได้ ทำให้เราสับสนกับตัวเองและต้องสร้างตัวตนใหม่ไปตามที่คนคนนั้นพอใจ จนเราเองเริ่มเกิดคำถามว่าจริงๆแล้วตัวตนของเราจริงๆเป็นแบบไหน
คณะวิศวกรรมศาสตร์
ยานยนต์ไฟฟ้าดัดแปลง
คณะวิศวกรรมศาสตร์
Nowadays, rail transportation has a significant impact on people's lives and economic growth. Consequently, the number of rail systems being built around our country has dramatically increased. This process causes various types of pollution, such as noise and rail-way vibration, which can badly affect the life of citizens who live nearby. The most popular way to solve this problem recently is to decrease the noise from the sound source or to adjust the vibration by attaching a Track Damper to the railway. This technique is being used in many countries especially in Europe and Australia because it is cheap and has high efficiency. The key piece called Track Dampers are made by AUT company’s Thailand for a period of time. The company produces Track Dampers for the owner of the technology so as to sell more than 300,000 pieces of it overseas. Furthermore, the demand of Track Dampers grows as the railway systems expand. Unfortunately, the imported synthetic materials, which are used to create Track Dampers, are made from environmentally unfriendly sources. As a result, this research aims to develop the product to be environmentally-safe by replacing some imported materials with Thai’s local content; which are natural rubber and rubber crumbs. Furthermore, the product will be added value by mounting with embedded sensors for real-time monitoring of track vibration, noise, and rail temperature. All embedded devices developed will sense, collect, and automatically send to cloud by wireless technology platform. The AI and IOT platform will also be developed for safety, security, and maintenance proposed of railway track system. However, in conducting research, there will be close collaboration with AUT company through design, production, and testing. The outcome of this research is to upgrade AUT company from tier 2 manufacturer (TRL 8-9) to tier 1 manufacturer (TRL 7-8) which will be served the Thailand competitiveness enhancing strategic goal.
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.