This experiment aimed to study the suitable types of polymers for coating with chlorophyll extract and the quality of cucumber seeds after coating. The experiment was planned using a Completely Randomized Design (CRD) with four replications, consisting of five methods involving seeds coated with different types of polymers: Polyvinylpyrrolidone, Sodium Alginate, Carboxy Methyl Cellulose, and Hydroxypropyl Methylcellulose, each polymer being coated alongside chlorophyll, with uncoated seeds serving as the control method. The coating substance was prepared by extracting chlorophyll from mango leaves, then mixed with each type of polymer at a concentration of 1%, using an 8% concentration of chlorophyll extract. The properties of each coating method, such as pH and viscosity of the coating substance, were examined before coating the cucumber seeds with a rotary disk coater model RRC150 at a coating rate of 1,100 milliliters per 1 kilogram of seeds. Subsequently, the seeds were dried to reach the initial moisture level using a hot air blower, and seed quality was assessed in various aspects, including seed moisture, germination rate under laboratory conditions, germination index, and seed fluorescence under a portable ultraviolet light illuminator, as well as light emission spectrum analysis using a Spectrophotometer. The experiment found that each type of polymer could be used to form a film together with chlorophyll, which had appropriate pH and viscosity for the coating without affecting seed quality and showed fluorescence on the seed surface both under portable ultraviolet light and spectral emission analysis with a Spectrophotometer. Using HPMC as the film-forming agent with chlorophyll was the most suitable method, enhancing seed fluorescence efficiency.
สารเรืองแสงที่นิยมใช้เคลือบเมล็ดพันธุ์ในปัจจุบันมีหลายชนิด เช่น Rhodamine B, Curcumin, Auramine O แต่สารเหล่านี้บางชนิดหากใช้ไปเป็นเวลานานอาจเป็นพิษต่อร่างกายมนุษย์ หากสะสมในร่างกายอาจก่อให้เกิด oxidative stress ซึ่งกระตุ้นให้เซลล์เกิดการเสียหาย เพิ่มความเสี่ยงของโรคบางอย่างได้ ในงานวิจัยนี้จึงเลือกใช้สารสกัดจากธรรมชาติมาใช้เคลือบเมล็ดพันธุ์ คือ สารสกัดคลอโรฟิลล์ มีข้อดี คือ หาได้ง่าย มีวิธีการสกัดที่ไม่ซับซ้อน แต่ข้อจำกัดของสารสกัดคลอโรฟิลล์คือมีความสามารถในการเคลือบร่วมกับพอลิเมอร์ได้บางชนิด อาจทำให้ประสิทธิการเรืองแสงมีคุณภาพลดลง ดังนั้นการวิจัยนี้จึงมีวัตถุประสงค์เพื่อหาชนิดของพอลิเมอร์ที่เหมาะสมในการนำมาเคลือบร่วมกับสารสกัดคลอโรฟิลล์แล้วไม่ส่งผลต่อประสิทธิภาพการเรืองแสงและคุณภาพของเมล็ดพันธุ์
คณะวิศวกรรมศาสตร์
The purpose of this invention is to develop a forest fire prevention agent that has the ability to prevent long-term forest fires, not only to suppress forest fires or prevent forest fires from spreading widely, but to prevent them from starting to catch fire from the beginning. It can prevent forest fires comprehensively and can be prevented for a long time during the peak forest fire period or the dry season, which is about 3-4 months. There are no residues or minimal residues without causing harm to the surrounding environment under the specified standards. Emphasis is placed on the use of raw materials, equipment, and chemicals that can be easily found in Thailand. This includes using the value of production costs as low as possible. This makes it suitable for use in large quantities for spraying and protecting forest areas in forest areas that are prone to fire. Estimated average for pollution caused by forest fires include particulate matter (PM), including PM2.5, PM10, carbon monoxide (CO), carbon dioxide, carbon dioxide, and carbon dioxide, Nitrogendioxide, VOC etc.
วิทยาลัยการจัดการนวัตกรรมและอุตสาหกรรม
Air Rack is a product designed to address businesses with limited space and budget constraints for server rooms, cooling systems, and noise management. This system enables efficient use of IT equipment in open spaces, supporting both On-premise and On-cloud operations. It converts sensor data into digital information and displays it via a Dashboard, allowing users to monitor, analyze, and control the system remotely. Additionally, Air Rack significantly reduces power consumption and the costs associated with traditional server room management.
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.