Direct Arc Plasma Generator with Six Nozzles, Applications of Plasma Technology and Progress in Nuclear Fusion and Thailand Tokamak-1 (TT1) Development
เทคโนโลยีพลาสมาเป็นนวัตกรรมที่สำคัญในอุตสาหกรรมการผลิต อิเล็กทรอนิกส์ และการแพทย์ โดยช่วยเพิ่มประสิทธิภาพและคุณภาพของผลิตภัณฑ์ อีกทั้งยังมีบทบาทสำคัญในพลังงานสะอาด เช่น โทคามัค ซึ่งใช้พลาสมาในการสร้างปฏิกิริยาฟิวชันเพื่อผลิตพลังงานจากไฮโดรเจนอย่างยั่งยืน โทคามัคมีศักยภาพในการลดการพึ่งพาเชื้อเพลิงฟอสซิลและแก้ไขปัญหาการเปลี่ยนแปลงสภาพภูมิอากาศ ทำให้เป็นกุญแจสำคัญสู่พลังงานแห่งอนาคต
คณะวิศวกรรมศาสตร์
This project aims to design and develop an electric tuk-tuk by converting the traditional combustion engine system to an electric system, supporting the reduction of air pollution and promoting sustainable automotive technology. The electric tuk-tuk is designed using a BLDC electric motor and a control system specifically adapted for the unique driving style of three-wheeled vehicles in Thailand. The study considers suitable energy systems and includes interviews with traditional tuk-tuk drivers to ensure the vehicle meets everyday usability needs. The findings suggest that adopting electric tuk-tuks not only reduces emissions and PM2.5 particulate matter but also enhances an eco-friendly image for Thailand’s tourism sector while supporting domestic innovation and economic growth.
คณะวิทยาศาสตร์
In this paper, Vanadium dioxide (VO2) thin-film devices with two different use cases have been redesigned to introduce an asymmetrical resonant cavity structure. The structure is designed with the goal of enhancing the optical performance of the central VO2 layer and has an anti-reflection property in the cold state. The advantages and limitations of such a design are discussed.
คณะแพทยศาสตร์
Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.