Migraine, a prevalent neurological disorder, is the third most common disease globally, causing significant health and financial burdens. It has four stages: prodrome, aura, headache, and postdrome. The prodrome (also known as premonitory) stage is crucial as it precedes the headache by up to 72 hours. Taking medication during the premonitory peroid has shown to prevent the headache phase . However, the symptoms of premonitory period lack specificity, making it difficult for patients to know if they’re experiencing premonitory symptoms. Calcitonin-gene related peptide (cGRP),is a protein that plays a key role in migraine pathogenesis and studies found that salivary cGRP levels increase during the premonitory stage. This study aims to develop and evaluate a lateral flow immunoassay kit for detecting salivary cGRP levels in migraine patients during the prodrome stage. It can serve as a confirmation tool for premonitory symptoms.
This study has the potential to greatly improve the management and prevention of migraine. The early detection and management could potentially reduce the frequency and severity of migraines, thereby improving the quality of life for patients and reducing their overall burden. Moreover, the confirmatory test for premonitory symptoms provided by this study could help reduce medication overuse, resulting in cost savings for patients, minimizing potential side effects, and potentially lowers the incidence of medication-overuse headaches. Additionally, by providing patients with a predictive tool, the study promotes patient-centered care and encourages patients to take an active role in managing their migraines. The study may also increase awareness and education surrounding premonitory symptoms. Furthermore, if successful, this study could open up for more new, non-invasive, reliable, and accessible approaches to migraine management and prevention.
คณะสถาปัตยกรรม ศิลปะและการออกแบบ
This study aims to identify the toothbrush appearance factors that affect baby boomers purchasing decisions. The research divide into three stages: The first stage is to classify the toothbrush appearance factors through a review of literature, research, and examining toothbrushes currently available on the market, summarizing them as appearance factors. The second stage is to summarize the results of the toothbrush appearance factors to create a multiple-choice questionnaire in three dimensions: purchasing decisions, aesthetics, and functionality. Collecting data from a group of 30 Baby Boomers aged 57-75 years old. The last stage is to summarize the three dimensions of appearance factors affecting baby boomers' toothbrush purchasing decisions and report as percentages and rank them. The research findings indicate that the most significant toothbrush appearance factor is a "Curved handle," accounting for 80%, followed by “Multi-level bristles” at 70%, a "Rubber thumb rest" at 53.3%, "Handle divided into more than two parts" at 50%, and “Offset shape” at 40%, respectively. In terms of the reason for purchasing decision based on various factors are as follows: the curved handle and offset shape give a sense of purchase with its aesthetic, While the selection of multi-level bristles, the Rubber thumb rest, and the handle divided into more than two parts due to functionality.
คณะวิศวกรรมศาสตร์
This thesis presents the development of an IoT system that integrates various communication standards to work together seamlessly. The Core Board serves as the IoT gateway, connecting LoRa, Wi-Fi, and BLE interfaces, and is powered by the STM32H563Zi microcontroller based on the ARM Cortex M33 architecture. The system is designed with slots to support additional communication standards and includes a web platform for data monitoring.
คณะวิทยาศาสตร์
Bacteriocins are microbial peptides that demonstrate potency against pathogens. This study evaluated the inhibitory effects on pathogens and characterized the bacteriogenomic profile of strain TKP1-5, isolated from the feces of Anas platyrhynchos domesticus. Strain TKP1-5 was characterized using phenotypic traits, 16S rRNA sequencing, and Whole-Genome Sequencing (WGS). It exhibited growth in the presence of 2-6% NaCl, temperatures of 25-45°C, and pH levels ranging from 3 to 9. Based on ANIb, ANIm, and dDDH values, strain TKP1-5 was identified as Lactococcus lactis. Whole genome analysis revealed that strain TKP1-5 harbors the Nisin Z peptide gene cluster with a bit-score of 114.775. The antimicrobial spectrum of bacteriocin TKP1-5 showed inhibitory effects against pathogenic bacteria including Pediococcus pentosaceus JCM5885, Listeria monocytogenes ATCC 19115, Enterococcus faecalis JCM 5803T, Salmonella Typhimurium ATCC 13311ᵀ, Aeromonas hydrophila B1 AhB1, Streptococcus agalactiae 1611 and Streptococcus cowan I. Genomic analysis confirmed L. lactis TKP1-5 as a non-human pathogen without antibiotic resistance genes or plasmids. Furthermore, L. lactis TKP1-5 contains potential genes associated with various probiotic properties and health benefits. This suggests that L. lactis TKP1-5, with its antibacterial activity and probiotic potential, could be a promising candidate for further research and application in the food industry.