Migraine, a prevalent neurological disorder, is the third most common disease globally, causing significant health and financial burdens. It has four stages: prodrome, aura, headache, and postdrome. The prodrome (also known as premonitory) stage is crucial as it precedes the headache by up to 72 hours. Taking medication during the premonitory peroid has shown to prevent the headache phase . However, the symptoms of premonitory period lack specificity, making it difficult for patients to know if they’re experiencing premonitory symptoms. Calcitonin-gene related peptide (cGRP),is a protein that plays a key role in migraine pathogenesis and studies found that salivary cGRP levels increase during the premonitory stage. This study aims to develop and evaluate a lateral flow immunoassay kit for detecting salivary cGRP levels in migraine patients during the prodrome stage. It can serve as a confirmation tool for premonitory symptoms.
This study has the potential to greatly improve the management and prevention of migraine. The early detection and management could potentially reduce the frequency and severity of migraines, thereby improving the quality of life for patients and reducing their overall burden. Moreover, the confirmatory test for premonitory symptoms provided by this study could help reduce medication overuse, resulting in cost savings for patients, minimizing potential side effects, and potentially lowers the incidence of medication-overuse headaches. Additionally, by providing patients with a predictive tool, the study promotes patient-centered care and encourages patients to take an active role in managing their migraines. The study may also increase awareness and education surrounding premonitory symptoms. Furthermore, if successful, this study could open up for more new, non-invasive, reliable, and accessible approaches to migraine management and prevention.
คณะวิศวกรรมศาสตร์
This project presents an interactive kiosk system designed to facilitate students, staff, and visitors within the university campus. The kiosk provides real-time event updates, news, and university document access via QR codes or email. It integrates a 3D map of the engineering department with navigation assistance, allowing users to locate offices and other facilities efficiently. Additionally, it features a room booking system, enabling users to reserve spaces through an online platform and check in via QR code scanning at the kiosk. By integrating digital technology and smart urban solutions, this system enhances accessibility, campus management, and visitor experience.
คณะวิทยาศาสตร์
Metallic nanoparticles embedded in cellulose nanocrystal (MNPs/CNC) films were prepared by solution casting for antimicrobial and fungus in edible peel fruit. MNPs/CNC was synthesized by ultrasonic waves. The as-synthesized was characterized by the chemical characteristics by the transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction analysis (XRD), Fourier transform infrared spectrometer (FT-IR), zeta potential analyzer, and UV-visible spectrophotometer. MNPs/CNC films had high potential in antimicrobial and fungus. Therefore, MNPs/CNC can be used to wrap edible peeled fruit to inhibit the growth of microorganisms, which can effectively extend the shelf life of fruits.
คณะเทคโนโลยีการเกษตร
This experiment aimed to study the suitable types of polymers for coating with chlorophyll extract and the quality of cucumber seeds after coating. The experiment was planned using a Completely Randomized Design (CRD) with four replications, consisting of five methods involving seeds coated with different types of polymers: Polyvinylpyrrolidone, Sodium Alginate, Carboxy Methyl Cellulose, and Hydroxypropyl Methylcellulose, each polymer being coated alongside chlorophyll, with uncoated seeds serving as the control method. The coating substance was prepared by extracting chlorophyll from mango leaves, then mixed with each type of polymer at a concentration of 1%, using an 8% concentration of chlorophyll extract. The properties of each coating method, such as pH and viscosity of the coating substance, were examined before coating the cucumber seeds with a rotary disk coater model RRC150 at a coating rate of 1,100 milliliters per 1 kilogram of seeds. Subsequently, the seeds were dried to reach the initial moisture level using a hot air blower, and seed quality was assessed in various aspects, including seed moisture, germination rate under laboratory conditions, germination index, and seed fluorescence under a portable ultraviolet light illuminator, as well as light emission spectrum analysis using a Spectrophotometer. The experiment found that each type of polymer could be used to form a film together with chlorophyll, which had appropriate pH and viscosity for the coating without affecting seed quality and showed fluorescence on the seed surface both under portable ultraviolet light and spectral emission analysis with a Spectrophotometer. Using HPMC as the film-forming agent with chlorophyll was the most suitable method, enhancing seed fluorescence efficiency.