Migraine, a prevalent neurological disorder, is the third most common disease globally, causing significant health and financial burdens. It has four stages: prodrome, aura, headache, and postdrome. The prodrome (also known as premonitory) stage is crucial as it precedes the headache by up to 72 hours. Taking medication during the premonitory peroid has shown to prevent the headache phase . However, the symptoms of premonitory period lack specificity, making it difficult for patients to know if they’re experiencing premonitory symptoms. Calcitonin-gene related peptide (cGRP),is a protein that plays a key role in migraine pathogenesis and studies found that salivary cGRP levels increase during the premonitory stage. This study aims to develop and evaluate a lateral flow immunoassay kit for detecting salivary cGRP levels in migraine patients during the prodrome stage. It can serve as a confirmation tool for premonitory symptoms.
This study has the potential to greatly improve the management and prevention of migraine. The early detection and management could potentially reduce the frequency and severity of migraines, thereby improving the quality of life for patients and reducing their overall burden. Moreover, the confirmatory test for premonitory symptoms provided by this study could help reduce medication overuse, resulting in cost savings for patients, minimizing potential side effects, and potentially lowers the incidence of medication-overuse headaches. Additionally, by providing patients with a predictive tool, the study promotes patient-centered care and encourages patients to take an active role in managing their migraines. The study may also increase awareness and education surrounding premonitory symptoms. Furthermore, if successful, this study could open up for more new, non-invasive, reliable, and accessible approaches to migraine management and prevention.
คณะวิทยาศาสตร์
The species Enterococcus lactis is closely related to E. faecium and is known for its beneficial and probiotic effects. In this study, strain RRS4 was isolated from Raphanus sativus Linn. and identified based on both phenotypic and genotypic characteristics. Strain RRS4 exhibited cell viability in environments with 2-8% NaCl, pH ranging from 4 to 9, and temperatures between 4°C and 45°C. Through comprehensive genomic analysis, strain RRS4 was confirmed to be E. lactis. E. lactis RRS4 demonstrated inhibitory effects against Vancomycin-resistant E. faecalis JCM 5803. Safety assessments via in silico methods, including KEGG annotation, indicated the absence of virulent and undesirable genes in E. lactis RRS4. VirulenceFinder analysis aligned virulence-related genes with those from three strains of E. lactis and four strains of E. faecium. While antibiotic resistance genes were found to be conserved, they did not correlate with key pathogenicity traits. Furthermore, safety evaluations highlighted that E. lactis RRS4 is generally safe, despite the presence of genes associated with antibiotic resistance. Lastly, we propose guidelines for assessing the safety of microbial strains using whole-genome analysis. These findings represent advancements in probiotic research.
คณะวิศวกรรมศาสตร์
A high-pressure gas storage tank made from composite materials, including carbon fiber, resin, and plastic, is designed for storing compressed natural gas (CNG) or hydrogen. This type of tank is classified as a Type IV high-pressure vessel. In this research, it is designed to operate at a pressure of 250 bar for the transportation of compressed natural gas.
คณะเทคโนโลยีการเกษตร
The design site of 22 hectares of agricultural land in this area is located in Tatata District, Iglenburg Province. The design concept of this area aims to encourage farmers and communities to earn income from the agricultural products produced in this area, and emphasizes that this area is a "living market", which can not only create food from a variety of crops, but also establish a balanced ecosystem and promote biodiversity in this area. The market will become a sustainable market area, which is not only beneficial to society in promoting economy, but also beneficial to the environment. The area will serve as a social and learning center, where community members can fully exchange agricultural information and experience and stimulate the economy in the community in another way.