Innovation Owner
Mr. SALIN HATAKAROON
Student
Details
Migraine is a prevalent neurological disorder with four distinct stages. This study aims to develop a lateral flow immunoassay kit to detect salivary cGRP levels during the premonitory stage, enabling early intervention and effective headache prevention.
Migraine is a prevalent neurological disorder and the third most common disease globally, causing significant health and financial burdens. It consists of four stages:
- Prodrome (premonitory)
- Aura
- Headache
- Postdrome
The prodrome stage is crucial as it precedes the headache by up to 72 hours. Taking medication during this period has been shown to prevent the headache phase; however, symptoms often lack specificity, making it difficult for patients to identify them.
Calcitonin-gene related peptide (cGRP) is a protein that plays a key role in migraine pathogenesis, with studies showing that salivary cGRP levels increase during the premonitory stage. This study aims to develop and evaluate a lateral flow immunoassay kit for detecting salivary cGRP levels, serving as a confirmation tool for premonitory symptoms.
Objective
This study proposes to develop and evaluate the effectiveness of a lateral flow immunoassay kit for detecting salivary cGRP levels in patients with migraine during the premonitory stage, serving as a confirmation tool for premonitory symptoms.
This study proposes to develop and evaluate the effectiveness of a lateral flow immunoassay kit for detecting salivary cGRP levels in patients with migraine during the premonitory stage, serving as a confirmation tool for premonitory symptoms.