Migraine, a prevalent neurological disorder, is the third most common disease globally, causing significant health and financial burdens. It has four stages: prodrome, aura, headache, and postdrome. The prodrome (also known as premonitory) stage is crucial as it precedes the headache by up to 72 hours. Taking medication during the premonitory peroid has shown to prevent the headache phase . However, the symptoms of premonitory period lack specificity, making it difficult for patients to know if they’re experiencing premonitory symptoms. Calcitonin-gene related peptide (cGRP),is a protein that plays a key role in migraine pathogenesis and studies found that salivary cGRP levels increase during the premonitory stage. This study aims to develop and evaluate a lateral flow immunoassay kit for detecting salivary cGRP levels in migraine patients during the prodrome stage. It can serve as a confirmation tool for premonitory symptoms.
This study has the potential to greatly improve the management and prevention of migraine. The early detection and management could potentially reduce the frequency and severity of migraines, thereby improving the quality of life for patients and reducing their overall burden. Moreover, the confirmatory test for premonitory symptoms provided by this study could help reduce medication overuse, resulting in cost savings for patients, minimizing potential side effects, and potentially lowers the incidence of medication-overuse headaches. Additionally, by providing patients with a predictive tool, the study promotes patient-centered care and encourages patients to take an active role in managing their migraines. The study may also increase awareness and education surrounding premonitory symptoms. Furthermore, if successful, this study could open up for more new, non-invasive, reliable, and accessible approaches to migraine management and prevention.
คณะครุศาสตร์อุตสาหกรรมและเทคโนโลยี
This research confirms the potential of bamboo fiber as a sustainable raw material for the textile industry, demonstrating exceptional properties that meet both functional requirements and environmental friendliness. The study focuses on integrating sustainability concepts with material innovation, encompassing fiber property analysis, production process development, and product design. The research objectives were to: 1) develop the properties of bamboo fiber for production; 2) study factors in designing environmentally friendly textile products from bamboo fiber; and 3) forecast future prospects for environmentally friendly textile product design using bamboo fiber. The findings revealed that 60-day-old bamboo possessed optimal properties for fiber separation, with an average fiber size of 5.32 μm, smaller than other natural fibers, resulting in superior moisture absorption and ventilation properties. When blended with recycled polyester fiber in a 30:70 ratio, the yarn exhibited strength and unique tactile characteristics. Although the antibacterial properties against Staphylococcus aureus were low, the fibers demonstrated excellent whiteness and softness. Factor analysis identified four key components in product design: Local Materials, Green Products, Healthy, and Sustainability. Consumer satisfaction evaluation of the prototype products showed high levels of acceptance, with the model explaining 84.7% of consumer satisfaction. The developed production process reduced chemical usage and hazardous waste. Furthermore, utilizing fast-growing bamboo minimized long-term environmental impact, contributing to sustainable development in Thailand's rural communities across economic, environmental, and occupational stability dimensions. The research demonstrates that developing bamboo fiber blended with recycled polyester creates sustainable products that meet consumer demands for health consciousness, local material utilization, and green product promotion. Commercial implementation of these products can enhance economic value and promote environmentally friendly product development in the future.
คณะเทคโนโลยีการเกษตร
Major medical and veterinary pests including the mosquitoes, houseflies and cockroaches pose health problems for humans and mammals and create more visual obstruction. Therefore, this research discovered a formula of essential oils and active ingredients from herbal plants that are highly effective in controlling and eliminating these insects compared to chemical insecticides, are safe for non-target organisms living in the environment, and are stable and maintain the active properties of the compounds. These formulas can be developed into environmentally friendly natural products to replace or reduce the use of chemical insecticides.
คณะเทคโนโลยีการเกษตร
This study aimed to investigate the efficacy of lime containing more than 50% calcium oxide and not less than 29% magnesium oxide in enhancing water alkalinity for Pacific White Shrimp (Litopenaeus vannamei) aquaculture. The experiment was conducted at concentrations of 0, 5, 10, 15, and 20 ppm over a 48-hour period, with data collected at 0, 3, 6, 12, 24, 36, and 48 hours. Results demonstrated that lime exhibited high dissolution efficiency (65-86%) within the first hour and reached complete dissolution (98.5-98.6%) within 6 hours. The pH values initially increased proportionally with lime concentration, gradually decreased during 3-12 hours, before stabilizing. Total alkalinity showed significant increase during the first 3-6 hours and remained stable until the end of the experiment. Statistical analysis revealed that both concentration and time significantly affected all parameters (p < 0.001)