This research aims to evaluate the efficiency of nano-type oxygen diffusers at different pump power levels in sea bass nursery ponds. The study examines how varying power levels affect dissolved oxygen distribution in the water and their impact on the health, growth, and survival rates of sea bass. The findings indicate that pump power levels influence dissolved oxygen concentration, with the optimal power level improving oxygen distribution in the pond. This enhancement leads to higher survival and growth rates for sea bass. The results provide valuable insights for selecting appropriate oxygen diffusers and pump power levels in fish nursery pond systems. The experiment consisted of two conditions: 1. Without fish – This condition assessed the oxygenation capacity, oxygen transfer coefficient, oxygen transfer rate, and oxygen transfer efficiency of pumps at three different power levels. 2. With fish – This condition evaluated whether the oxygen supplied by pumps at three power levels was sufficient, based on the growth rate and survival rate of the fish in the pond. Blood counts were conducted to assess the immune response. The collected data were statistically analyzed using the RCBD method for the condition without fish and the CRD method for the condition with fish, employing SPSS software.
ประเทศไทยได้ประสบปัญหาในเรื่องของภัยธรรมชาติ ปัญหาการเปลี่ยนเเปลงสภาพภูมิอากาศ โดยเฉพาะปัญหาอุทกภัยและภัยเเล้ง สภาพอากาศแปรปรวน และยังมีปัญหาในด้านการทำประมงที่จำกัดดังนั้นการทำฟาร์มเลี้ยงสัตว์น้ำเเบบลดความเสี่ยงจึงเป็นทางออกในการรักษาความมั่นคงของอาหาร ในปัจจุบันปลาที่สามารถปรับตัวให้อยู่ในน้ำจืดหรือน้ำกร่อยได้และเป็นที่นิยมในการรับประทานได้เเก่ปลากะพงขาว เนื่องจากเลี้ยงง่ายโตเร็ว เนื้อปลารสชาติดี และมีราคาสูงพอคุ้มค่ากับการลงทุน โดยศึกษาจากการใช้อุปกรณ์สร้างออกซิเจนชนิดหัวนาโนบับเบิ้ลเพื่อศึกษาว่าอุปกรณ์ให้ออกซิเจนชนิดหัวนาโนกับขนาดกำลังปั๊มน้ำที่ต่างกันขนาดใดมีความสามารถทำให้ออกซิเจนละลายในน้ำดีมากที่สุด อัตราการถ่ายเทออกซิเจนในน้ำ ค่าสัมประสิทธิ์ออกซิเจนที่ละลายในน้ำได้มีประสิทธิภาพมากที่สุด วัดความเจริญเติบโต อัตรารอดของปลากะพงและภูมิคุ้มกันของปลากะพง ประสิทธิภาพในการให้ ออกซิเจน ในบ่ออนุบาลปลากะพงได้ดีที่สุดและมีผลกระทบน้อยมากที่สุด
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
คณะเทคโนโลยีสารสนเทศ
KinderForest : Puzzle Building Game with VR Technology is designed to utilize Virtual Reality (VR) technology with the primary aim of promoting creative problem-solving skills and basic practical application abilities among players. This project presents the game in an Augmented Virtual Reality (AR VR) format, emphasizing physical engagement of players during gameplay while fostering creativity and fundamental application skills. The project team has chosen to utilize Unreal Engine 5.1 and Oculus Quest 2 virtual reality glasses to develop the game in the form of augmented virtual reality technology. Within the game, there will be various levels that require creative thinking and different approaches to pass. Time constraints will be a crucial element in completing missions and progressing through these levels. Players will physically move their bodies in response to in-game movements. Each level will present unique challenges that will necessitate both physical movement and problem-solving skills. The game will provide different rewards based on the outcomes of mission completion, and players will be informed of their results once they have successfully passed a level.
คณะวิศวกรรมศาสตร์
The project uses artificial intelligence (AI) and deep learning to develop a smart police system (Smart Police) to analyze the identity of individuals and vehicles suspected of involvement in crimes. The system uses CCTV cameras to detect people with concealed weapons and track vehicles involved in crimes. The system also sends alerts to the police when a crime is detected. The Smart Police system is a collaboration between the Faculty of Engineering, King Mongkut's Institute of Technology Ladkrabang, the Provincial Police Region 2, the Chachoengsao Foundation for Development, and the Smart City Office of Chachoengsao Province. The system is designed to prevent and deter crime, increase public safety and order, and build a network of cooperation between the government, the private sector, and the community. The system is currently under development, but it has the potential to be a valuable tool for law enforcement. The system could help to reduce crime and improve public safety in Chachoengsao Province and other parts of Thailand.