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Tree Planting Application for Dormitories

Abstract

This project involves the development of a plant care system for dormitories using IoT (Internet of Things). The system is implemented through programming on an ESP-32 board and controlled via sensors for automated watering. The commands are operated through smartphones, supporting both iOS and Android. It is expected that this project will make plant care in dormitories easier and more convenient.

Objective

ในปัจจุบันหลายพื้นที่ในเมืองมีความหนาแน่นของประชากรสูง เช่นหอพัก คอนโดมิเนียม หรือ อพาต์เม้น มักมีพื้นที่จำกัดสำหรับการปลูกต้นไม้ซึ่งเป็นไปใจในการสร้างสภาพแวดล้อมที่ดีและสุขภาพที่ดีให้กับผู้อยู่อาศัย การสร้างแอพพลิเคชันปลูกต้นไม้นี้ขึ้นมาเพื่อให้ผู้อาศัยสามารถปลูกต้นไม้ได้ในพื้นที่จำกัดและสามารถดูแลต้นไม้ได้เหมาะกับคนรุ่นใหม่ที่ไม่มีเวลาในการดูแลต้นไม้ก็สามารถปลูกพืชได้ซึ่งแอพพลิเคชันนี้ได้ออกแบบเพื่อให้ผู้ใช้งานสามารถเลือกต้นไม้ที่เหมาะสมกับพื้นที่จำกัดและมีคำแนะนำสำหรับการดูแลต้นไม้แก่ผู้ที่สนใจหรือต้องการศึกษา ด้วยความสำคัญดังกล่าว แอพพลิเคชันปลูกต้นไม้นี้ไม่เพียงแต่อำนวยความสะดวกให้กับผู้ใช้งานแต่ยังเป็นการสนับสนุนการพัฒนาที่ยั่งยืนและเต็มไปด้วยพื้นที่สีเขียว

Other Innovations

Decoding the Impact of RGL3 Genetic Variants on Protein Structure and Binding Site: A Bioinformatics Approach to Uncover Potential Hypertension Associations

คณะแพทยศาสตร์

Decoding the Impact of RGL3 Genetic Variants on Protein Structure and Binding Site: A Bioinformatics Approach to Uncover Potential Hypertension Associations

Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.

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Plasma technology and nuclear fusion

คณะวิทยาศาสตร์

Plasma technology and nuclear fusion

Direct Arc Plasma Generator with Six Nozzles, Applications of Plasma Technology and Progress in Nuclear Fusion and Thailand Tokamak-1 (TT1) Development

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Enhancing the efficiency of in-ear monitors for hearing-impaired musicians

วิทยาลัยวิศวกรรมสังคีต

Enhancing the efficiency of in-ear monitors for hearing-impaired musicians

Some musicians are hearing impaired, some have finished their careers, but some continue to work, and it is much harder for them to be deaf than for musicians who are not. Some use hearing aids in their daily lives and use in-ear monitors in their live performances, which seem normal, but in their in-ears they only hear the metronome and drums. How can we improve the performance of in-ear monitors to near normal?

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