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The Effect of Cannabidiol on the Excitability of Nociceptive Trigeminal Ganglion Neurons

Abstract

This research studies the effect of CBD on the excitability of mice nociceptive trigeminal ganglion neurons. The electrophysiological parameters of the mouse trigeminal ganglion cells are measured using a Whole Cell Current Clamp Model on a primary cell culture treated with 0.5 uM CBD for 24 hours compared to a control group. After obtaining the results statistical analysis is done using a Mann Whitney-U test.

Objective

ยาที่ใช้ในกาารักษาอาการปวดในปัจจุบัน เช่น NSAIDs และยาโอปิออยด์อาจก่อให้เกิดผลข้างเคียงที่ไม่พึงประสงค์ ทำให้ไม่เหมาะสมสำหรับประชากรบางกลุ่มโดยเฉพาะผู้สูงอายุ ดังนั้นการศึกษานี้จึงทําเพื่อประเมินฤทธิของ CBD ต่อการลดความไวในการรับรู้ความเจ็บปวดเพื่อดูเป็นยาทางเลือกในการรักษาอาการปวดในอนาคต

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