This research studies the effect of CBD on the excitability of mice nociceptive trigeminal ganglion neurons. The electrophysiological parameters of the mouse trigeminal ganglion cells are measured using a Whole Cell Current Clamp Model on a primary cell culture treated with 0.5 uM CBD for 24 hours compared to a control group. After obtaining the results statistical analysis is done using a Mann Whitney-U test.
ยาที่ใช้ในกาารักษาอาการปวดในปัจจุบัน เช่น NSAIDs และยาโอปิออยด์อาจก่อให้เกิดผลข้างเคียงที่ไม่พึงประสงค์ ทำให้ไม่เหมาะสมสำหรับประชากรบางกลุ่มโดยเฉพาะผู้สูงอายุ ดังนั้นการศึกษานี้จึงทําเพื่อประเมินฤทธิของ CBD ต่อการลดความไวในการรับรู้ความเจ็บปวดเพื่อดูเป็นยาทางเลือกในการรักษาอาการปวดในอนาคต
คณะวิทยาศาสตร์
A new colorimetric assay for the rapid detection of tannic acid in beverage samples based on displacement phenomenon of aggregated gallic acid-modified platinum nanoparticles is developed for the first time. PtNPs were functionalized with gallic acid, promoting the formation of the green-hued aggregated nanoparticles. While colorimetry offers a rapid method for identifying tannic acid, challenges remain in sensitivity and accuracy of detection on the PtNPs colorimetric probe, particularly in the presence of anthocyanin interferences. To address this, we developed a sample preparation method to degrade anthocyanin in beverages. Tannic acid was easily displaced onto the gallic acid-coated PtNPs surfaces, causing dispersion and resulting in a visible color change from green to orange−brown. Under the optimal conditions, the colorimetric sensor exhibited a linear response in the range of 1−2,000 µmol L−1 (R2 = 0.9991). The limit of detection (LOD) and the limit of quantification (LOQ) were found at 0.02 and 0.09 µmol L−1, respectively. The proposed sensor expressed superior selectivity over other interfering substances and demonstrated excellent precision with a relative standard deviation (RSD) of 1.00%−3.36%. More importantly, recoveries ranging from 95.0−104.7% were obtained, indicating the capability of proposed colorimetric sensor to detect tannic acid rapidly and accurately in real beverage samples.
คณะสถาปัตยกรรม ศิลปะและการออกแบบ
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วิทยาเขตชุมพรเขตรอุดมศักดิ์
Study on Parasites in Blackchin Tilapia and Value-Added Processing Parasites play a crucial role in affecting fish health and the balance of marine ecosystems. The study of parasites in fish is essential for assessing fish population status and their impact on the ecosystem. This research focuses on a preliminary survey of parasites in Blackchin Tilapia (Sarotherodon melanotheron) found in the waters of Chumphon Province to determine whether this species carries parasitic infections. The findings will provide valuable insights for managing marine resources and developing strategies for processing Blackchin Tilapia into food products to help control its population in the ecosystem. One of the value-added processing approaches for Blackchin Tilapia is the "Nai Hoi Hua Fu" product. This product involves deep-frying the fish to achieve a crispy and fluffy texture before mixing it with mango salad to enhance its flavor and make it more appealing. This processing method not only adds value to the fish but also serves as a practical solution for managing the Blackchin Tilapia population, which may impact the ecosystem. The study results indicate that no parasitic infections were found in either the internal or external organs of the sampled fish, suggesting that the marine environment in the study area is favorable for fish health. However, continuous research is recommended to monitor long-term ecological changes and evaluate the impact of Blackchin Tilapia on ecosystem balance to ensure sustainable resource management.