The photoelectrochemical detection of salbutamol, which is illicitly used as a lean meat promoter in pigs, is investigated using a molecularly imprinted polymer (MIP)-based sensor with a CuO/g-C₃N₄ nanocomposite to enhance detection performance, leveraging nanomaterials and molecular imprinting for high selectivity and sensitivity. This approach offers a promising strategy for the precise and efficient analysis of salbutamol in food samples.
ความปลอดภัยทางด้านอาหารเป็นหนึ่งปัจจัยที่มีผลสำคัญต่อสุขภาพและการดำเนินชีวิตประจำวัน เนื่องมาจากปัญหาการปนเปื้อนของสารเคมีในอาหารซึ่งก่อให้เกิดปัญหาตามมา อาทิเช่น อาการเจ็บป่วยเล็กน้อย ผลข้างเคียงหรือโรคที่เกี่ยวกับทางเดินอาหาร ไปจนถึงทำให้เสียชีวิตได้ สารซาลบูทามอลเป็นสารที่หาซื้อได้ง่ายเนื่องจากเป็นยาที่ถูกใช้กับผู้ที่เป็นโรคหอบหืดหรือโรคที่เกี่ยวกับระบบหายใจเรื้อรัง โดยสารชนิดนี้ถูกใช้ในทางที่ผิด เช่น การโดปของนักกีฬาหรือเพื่อการเร่งเนื้อแดงในสัตว์ได้
คณะอุตสาหกรรมอาหาร
This study aimed to develop a formula and production process for snacks made from germinated brown rice flour and banana flour using the extrusion process. The results indicated that both germinated brown rice flour and banana flour could be effectively used as the main raw materials for snack production via extrusion. The proportion of flour in the formula and production conditions, such as moisture content of the raw materials, barrel temperature, and screw speed, significantly influenced the nutritional value, bioactive compound levels, and antioxidant activity of the final products.
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
คณะวิศวกรรมศาสตร์
In this project, we introduce Power Grid Analyzer (PGAz), an open-source software package based on MATLAB, specifically designed for analyzing and controlling future power grids. Initially, PGAz is equipped with four fundamental features: power flow (PF), optimal power flow (OPF), small-signal stability analysis (SSSA), and time-domain simulation (TS). At this stage, Part I concentrates on the development of PF and OPF. The formats of our developed tool are presented, along with its command prompts. In this part, we have developed several conventional yet effective methods in the PGAz package to address PF and OPF problems, including techniques such as the Newton-Raphson method, Gauss-Seidel method, Interior Point Method, Iwamoto’s method, Fast Decoupled Load Flow, Genetic Algorithm, and Particle Swarm Optimization. Additionally, it emphasizes important aspects, algorithms, and various case studies that have been tested against IEEE benchmarks ranging from the IEEE 5-bus to the IEEE 300-bus test systems. The results demonstrate the capabilities of PGAz for future educational and research applications in PF and OPF. Finally, we outline a plan for developing Part II, which will mainly focus on SSSA and TS.