This project aims to develop seafood dipping sauce and Jaew sauce in solid cube form to address the limitations of liquid sauces, which can be difficult to carry and prone to spillage, as well as powdered sauces, which may lose their texture and authentic flavor. The research and development process focuses on utilizing distinct ingredients and innovative production techniques to enhance the quality and functionality of the product. The primary objective of this project is to introduce an innovative solution that improves the convenience of consumption and transportation while preserving the original taste and quality of traditional dipping sauces. The expected outcome is a novel dipping sauce product in solid cube form that is easy to carry, minimizes the risk of spillage, and holds potential for commercial development in the food industry.
โครงงานนี้มีที่มาจากความต้องการนวัตกรรมที่เพิ่มความสะดวกในการบริโภคและขนส่งน้ำจิ้ม พร้อมทั้งรักษาคุณภาพและรสชาติดั้งเดิมให้ใกล้เคียงต้นตำรับมากที่สุด
คณะสถาปัตยกรรม ศิลปะและการออกแบบ
A natural representation of new beginnings.
คณะสถาปัตยกรรม ศิลปะและการออกแบบ
With the current cost of living situation in Thailand continuously rising, many recent graduates face challenges in managing their expenses in alignment with the increasing living costs. Food expenses, even for common street food, continue to surge with no sign of decreasing, despite improvements in raw material costs. Pay-Attention is a website platform designed to help recent graduates gain insights into managing and optimizing their food expenses effectively. It provides guidance on how to spend wisely, ensuring cost-effectiveness while maintaining adequate daily nutritional intake, without falling into monotonous eating habits.
คณะทันตแพทยศาสตร์
Objective or Background: Dental caries is still one of the most significant dental problems worldwide, with prevalence rates up to 90% among children and adults. Cariogenic bacteria, especially Streptococcus mutans, is the primary microorganism involved in the pathogenesis through carbohydrate metabolism and biofilm formation, which are challenging to eradicate. Histatin-5 (HST-5), a human salivary antimicrobial peptide, has demonstrated antimicrobial activity against various fungal and bacterial pathogens. Phytosphingosine (PHS), an endogenous bioactive sphingolipid found in fungi, plants, and humans, also shows antimicrobial properties. This study aimed to evaluate the killing activity of HST-5 alone and in combination with PHS against S. mutans under biofilm-stimulating conditions. Materials and Methods: Antimicrobial activity against a planktonic culture of S. mutans was evaluated using a time-kill assay, and biofilm-forming capacity was confirmed by crystal violet staining assay. The killing ability against 24h pre-formed biofilm was determined using Transferable Solid Phase (TSP) pin lid model. Synergistic activity between HST-5 and PHS was evaluated using the checkerboard technique. Additionally, the cytotoxicity of the tested agent on human gingival fibroblast cells (hGFs) was assessed after 1 h of incubation using an MTT assay. Results: A time-kill assay revealed that both HST-5 and PHS exhibit time- and concentration-dependent activity against the planktonic form of S. mutans. PHS achieved over 90% killing activity within 15 min at 5 μg/ml, whereas HST-5 required 30 min to reach 90% killing at 20 μM. The biofilm formation capacity of S. mutans was confirmed. The inhibitory concentrations (IC50) of HST-5 and PHS against S. mutans biofilm were 25 μM and 13.5 μg/ml, respectively. A synergistic interaction between HST-5 and PHS, with IC50 values reduced by 8-fold and 16-fold, respectively. No cytotoxic effects were observed in hGFs cells at the concentration of the synergistic interaction. Conclusions: Therefore, the combination of HST-5 and PHS may enhance the effectiveness of anti-infective agents against S. mutans biofilm, potentially preventing the development of dental caries.