The Public park project : Ancient Sea Park. This's a new park in Aangsila Chonburi make for learn and travel in concept The sea in 65 million years ago.
สวนเเห่งนี้เกิดจากความรู้เกี่ยวกับสิ่งมีชีวิตในท้องทะเลเมื่อ65ล้านปีก่อน ที่คนส่วนใหญ่รู้จักเพียงไดโนเสาร์ที่อยู่บนบกแต่ไม่คุ้นเคยกับสัตว์ดึกดำบรรพ์ใต้ท้องทะเล รวมกับอ่างศิลา เป็นพื้นที่ ที่มีสถานศึกษาบริเวณรอบพื้นที่ รวมทั้งสถานที่ท่องเที่ยว จึงได้เกิดเป็นสวนสาธารณะเเห่งนี้
วิทยาลัยนวัตกรรมการผลิตขั้นสูง
This research presents a Wilkinson power divider using a common inductor. The lumped topology uses the inherently inductive loss of the inductor as a part of the design, so the conventional resistor for high isolation can be omitted. Therefore, low-loss and high-isolation performances of the compact circuit were achieved. The proposed 2.5-GHz divider was implemented on a silicon-based integrated passive device process. Measurement of the prototype chip had a reflection coefficient below 18 dB at all ports, an insertion loss of 0.5 dB and isolation above 28 dB. The chip size is merely 0.011 wavelength x 0.019 wavelength.
คณะแพทยศาสตร์
Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.
คณะวิทยาศาสตร์
-