The research on improving the strength of solid electrolytes aims to enhance the properties of solid electrolyte materials produced from cement and additives that help develop the cement structure to generate electricity. The main components include sodium chloride (NaCl) and graphite, which contribute to the material’s ability to generate a weak electrical current. The objective is to develop an electricity-generating flooring material. This study involves preparing a mixture of cement, water, sodium chloride (NaCl), and graphite to enhance the material’s electrical conductivity. It is highly anticipated that this research will lead to the development of concrete flooring capable of generating electricity and can be further expanded for future applications.
ในปัจจุบัน ความต้องการใช้พลังงานไฟฟ้าเพิ่มขึ้นนอย่างต่อเนื่อง ส่งผลให้เกิดการพัฒนาเทคโนโลยีและนวัตกรรมใหม่ ๆ เพื่อเพิ่มแหล่งพลังงานทางเลือกที่มีความยั่งยืนและเป็นมิตรต่อสิ่งแวดล้อม หนึ่งในแนวทางที่ได้รับความสนใจ คือการพัฒนาวัสดุที่สามารถผลิตและกักเก็บพลังงานไฟฟ้าได้ในตัวเอง ซึ่งสามารถนำไปใช้ในโครงสร้างพื้นฐานต่าง ๆเช่น พื้นทางเดิน อาคาร หรือพื้นที่สาธารณะ ดังนั้น งานวิจัยนี้จึงมีเป้าหมายเพื่อพัฒนาและปรับปรุงคุณสมบัติของเซลล์อิเล็กโทรไลต์ชนิดแข็งที่มีโครงสร้างพื้นฐานจากซีเมนต์ โดยมุ่งเน้นการเพิ่มความแข็งแรงของวัสดุควบคู่ไปกับการรักษาคุณสมบัติการนำไฟฟ้า เพื่อให้สามารถนำไปใช้งานเป็นวัสดุปูพื้นที่สามารถผลิตกระแสไฟฟ้าได้ งานวิจัยนี้คาดหวังว่าจะเป็นแนวทางสำคัญในการ พัฒนาวัสดุก่อสร้างสามารถต่อยอดไปสู่การประยุกต์ใช้ในอนาคตได้อย่างมีประสิทธิภาพ
วิทยาลัยการจัดการนวัตกรรมและอุตสาหกรรม
Diabetes is a significant global health issue, particularly due to complications related to diabetic wounds. Studies indicate that approximately 15-25% of diabetic patients develop foot ulcers, with more than 50% of severe cases leading to amputation. This results in a substantial decline in the quality of life for patients. Current treatments for diabetic wounds face challenges such as antibiotic-resistant bacterial infections and delayed wound healing, highlighting the need for innovative solutions to accelerate the healing process and reduce the risk of limb loss. Cotylelobium lanceolatum Craib, a medicinal plant long utilized in traditional Thai medicine, is known for its anti-inflammatory and wound-healing properties. This study focuses on developing an extract from Cotylelobium lanceolatum Craib in the form of nano silver (Nano Silver) to enhance the effectiveness of diabetic wound treatment. Nano silver technology enables deeper penetration into the skin, provides potent antibacterial activity, and promotes wound healing by reducing inflammation and stimulating tissue regeneration. The development of nano silver derived from Cotylelobium lanceolatum Craib extract is expected to help reduce chronic wounds in diabetic patients, lower the risk of infection, and decrease the incidence of limb amputation and mortality associated with diabetic wound complications. This research represents a significant step toward creating a safer and more effective treatment alternative for diabetic wound care.
คณะแพทยศาสตร์
Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.
คณะเทคโนโลยีสารสนเทศ
Traditional methods of public relations and learning often lack engagement and fail to provide users with a deep and immersive experience. Additionally, these methods struggle to reach a wide audience, especially those unable to visit the physical location. This project aims to solve the issues of accessibility and awareness regarding the institution’s Chalermphrakiat Hall and historical exhibition. Utilizing metaverse technology to simulate important locations allows users to explore the site and view key information in a virtual format, thereby enhancing the engagement of students staff alumni and the general public. The metaverse system is developed using Unity, a powerful game engine capable of supporting the creation of metaverse environments. This allows for the creation of an interactive and realistic virtual space. Unity also supports the management of physics, lighting, and sound, further enhancing realism. Additionally, the system is integrated with web browsers using WebGL technology, enabling the project developed in Unity to be accessed directly through a browser. Users can visit and interact with the metaverse environment from anywhere without the need to install additional software. The developers have thus created the metaverse system to provide a realistic and engaging learning experience, enhancing public relations efforts and fostering a strong connection with the institution efficiently.