This piece represents the collection of all human elements, applied to design for maximum efficiency, following the principles of Modern designers who embraced the famous phrase "Form follows Function." Every line and structure of the design is carefully considered for user comfort and practical use, while reflecting the idea that the user's experience is central to the design process. The beauty emerges from the harmony between function and form, not only meeting functional needs but also enhancing the aesthetic of Modernist design in a complete and meaningful way.
เพื่อศึกษาเอกลักษณ์และความงามของศิลปะยุคModern และนำมาประยุกต์ใช้ในงานออกแบบ
คณะแพทยศาสตร์
Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.
คณะครุศาสตร์อุตสาหกรรมและเทคโนโลยี
The Research aims to create Computer Assisted Instruction (CAI) on Kitchen Design for Residence for 20 undergraduate students at the Interior Environmental Design Division, School of Industrial Education and Technology, King Mongkut’s Institute of Technology Ladkrabang. This CAI is a self-learning program for Interior environmental design courses focused on kitchen design for residences. The program is designed to interact with students to create learner engagement and improve learning achievement by providing course content and end-of-chapter quizzes. The research hypothesis is CAI: Interior Environmental Design: Kitchen design for residence affects learners’ learning achievement and students' knowledge toward learning by this CAI. The Development testing (DT) with E1/E2 is the criterion for this instructional media to examine learning achievement. The research findings indicate that CAI is an effective instructional media, scoring 71.50/89.00, which meets the criteria of 80/80, demonstrating students’ learning achievement. Students achieved higher scores than before by using Computer-Assisted Instruction (CAI).
คณะวิศวกรรมศาสตร์
One of the most important aspects of responding to a medical case is the response time. In general, most fatalities are due to the patient not being able to reach the hands of the doctor in time. This also includes the arrival of medical equipment to the scene. The human brain will start to degrade in function after 3 minutes of oxygen starvation which conventional road transportation method first responders presently use is usually unable to reach the site in this golden 3 minutes, resulting in fatalities during transport or before the arrival of first responders at the scene. Therefore, medical equipment transport by fully autonomous aircraft is explored. This is done through drone deliveries which is much quicker than road methods as the equipment could be flown straight to the site as it is not affected by traffic, road conditions, and navigation. In this project, we will explore an aerial delivery system for medical equipment such as Automatic External Defibrillators (AEDs), First aid equipment, and other small requested medical devices. This will be done through a DJI drone platform and their SDK application. The main goal for this project is to decrease the response time by using an autonomous aerial drone to deliver medical equipment.