This project presents a design and management approach for agricultural land in Kanchanaburi Province. The case study area is situated in Wangdong Subdistrict, Mueang Kanchanaburi District, covering an area of approximately 18 rai (7.2 acres). As the user seeks a simplified lifestyle in the countryside, surrounded by nature, the design aligns with this vision of simplicity and sustainability. The land is systematically allocated to optimize the benefits for both daily living and agricultural industry development. The crop cultivation zones are designed to suit the local climate and plant varieties, ensuring high-quality yields for continuous utilization. Meanwhile, the livestock zones are clearly delineated to maintain balance and organization. This approach not only ensures food security and income generation but also promotes a lifestyle that harmonizes with nature, minimizes environmental impact, and supports the long-term development of an efficient and eco-friendly agricultural industry. Comprehensive attention is given to the positioning of various zones, considering wind direction and sunlight exposure. Additionally, the design undergoes a rigorous drafting and review process to ensure the optimal outcomes for the land's utilization.
ผู้ใช้งานต้องการสร้างบ้านสวนเกษตรเพื่อใช้เป็นที่พักผ่อนอาศัยโดยมีพื้นที่สำหรับปลูกผักและผลไม้ รวมถึงโซนเลี้ยงสัตว์เพื่อสร้างรายได้จากการขาย ผลผลิตจากสวนและสัตว์เลี้ยงจะช่วยให้สามารถใช้ชีวิตอย่างยั่งยืนและพึ่งพาตนเองได้ รวมถึงเป็นการสร้างพื้นที่ที่ให้ความสงบและใกล้ชิดกับธรรมชาติ ซึ่งจะช่วยให้ผู้ใช้งานสามารถมีชีวิตที่สมดุล โดยไม่เพียงแต่เป็นสถานที่พักผ่อน แต่ยังเป็นแหล่งรายได้ที่มั่นคงในอนาคตด้วย
คณะเทคโนโลยีการเกษตร
Dwarf whipray (Brevitrygon heterura) is a common species found in a local market in the Gulf of Thailand. However, like many other species of stingrays, it is threatened by overfishing and habitat destruction. Therefore, an accurate species identification is crucial because conservation efforts may vary depending on the species. This study aims to understand morphological variation of B. heterura in the Gulf of Thailand by morphometric study and genetic analysis. During October 2022 and February 2023, we obtained 49 samples from research vessels fish landing ports and local fish markets. We observed two distinct groups based on 43 morphological variables/ratios. B. heterura samples from Chanthaburi, Rayong, Chonburi, Samut Sakhon, Nakhon Si Thammarat and Songkla provinces, called “group A," typically have longer snout length than those from Prachuap Khiri Khan provinces, called “group B" according to external morphological characters for species identification. Three morphological variables/ratios were significantly different between groups A and B. Main characters to explain intraspecific variations between group A and group B are further discussed. DNA barcoding based on a fragment of the cytochrome c oxidase subunit I (COI) gene were obtain from eight samples of group A and eight samples from group B. Pairwise percent sequence divergence (p-distance) for COI between group A and group B were 0.0-2.5. This study contributes to the understanding of variations of morphology and genetics of B. heterura in the Gulf of Thailand.
คณะวิทยาศาสตร์
Atopic dermatitis patients are the second largest number among skin disease patients. There is no cure for atopic dermatitis, and it can only be treated to relieve symptoms, causing chronic disease. There is a chance that opportunistic infections will enter and cause more disease from the patient's wound, causing the patient to have complications from other infections. This study is interested in studying the reduction of the chance of opportunistic infections in patients with atopic dermatitis using natural extracts. The interest is in Plu Kaow and long pepper because there is data supporting the inhibition of microorganisms. The leaves of both plants are crudely extracted, soaked in 95% ethanol for 7 days, filtered with a Buchner filter, and the extracts are tested for phytochemicals to analyze phenolic components, flavonoids, tannins, anthocyanin, DPPH, and tested for antimicrobial properties. The experiments consisted of 5 types of gram-positive and gram-negative bacteria: E. coli, Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. The researcher expects that this can be further developed and used to treat patients with atopic dermatitis.
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.