Aggregatibacter actinomycetemcomitans is a key pathogen in periodontal disease, damaging periodontal ligaments and alveolar bone through biofilm formation. D-LL-31, an engineered antimicrobial peptide, exhibits superior biofilm-killing ability compared to conventional treatments, while DNase I enhances its efficacy by disrupting the biofilm matrix. This study evaluated the combined effects of D-LL-31 and DNase I on A. actinomycetemcomitans biofilms. Results showed that D-LL-31 effectively eradicated biofilms, and its combination with DNase I further enhanced biofilm disruption without cytotoxicity to gingival epithelial cells. The D-LL-31 and DNase I combination shows potential for development as a mouthwash to improve oral health and combat periodontal disease.
โรคปริทันต์เป็นปัญหาสุขภาพช่องปากที่พบบ่อย โดยมี Aggregatibacter actinomycetemcomitans (Aa) เป็นหนึ่งในเชื้อก่อโรคสำคัญ เชื้อชนิดนี้สามารถสร้างไบโอฟิล์ม ซึ่งเป็นกลไกหลักที่ช่วยให้เชื้อดื้อยาต้านจุลชีพและหลบเลี่ยงระบบภูมิคุ้มกัน ทำให้การรักษาด้วยยาปฏิชีวนะทั่วไปไม่ได้ผลอย่างมีประสิทธิภาพ การพัฒนาแนวทางใหม่ในการกำจัดไบโอฟิล์มจึงเป็นสิ่งจำเป็น งานวิจัยนี้มุ่งเน้นศึกษาประสิทธิภาพของ D-LL-31 ซึ่งเป็นเปปไทด์ต้านจุลชีพที่ถูกแปลงทางวิศวกรรม เพื่อทำลายเชื้อที่อยู่ในไบโอฟิล์ม และการใช้ DNase I เพื่อสลายโครงสร้างเมทริกซ์ของไบโอฟิล์มร่วมกัน ซึ่งอาจเป็นแนวทางใหม่ในการพัฒนา น้ำยาบ้วนปาก ที่ช่วยลดเชื้อก่อโรคในช่องปากและป้องกันโรคปริทันต์ได้อย่างมีประสิทธิภาพ
คณะเทคโนโลยีการเกษตร
Currently, urban agriculture is gaining increasing attention as it helps enhance food security and expand green spaces in cities. However, some people remain uninterested in urban farming, possibly due to living in urban areas or having limited space, making them perceive agriculture as something distant from their daily lives. The development of an urban agriculture card game aims to promote learning about urban farming through an engaging and enjoyable gameplay experience.
คณะเทคโนโลยีการเกษตร
In the present day, interest in health and the consumption of chemical-free food has been steadily increasing, particularly in homegrown produce such as Phoenix oyster mushrooms (Pleurotus pulmonarius), which are highly nutritious and suitable for weight control. However, small-scale mushroom cultivation often faces challenges related to unsuitable environmental conditions, such as unstable temperature and humidity, which affect the growth and quality of the mushrooms. The development of an automatic temperature and humidity control system plays a crucial role in addressing these issues by utilizing sensor technology to monitor and adjust environmental conditions with precision. This helps enhance production efficiency, reduce human errors in manual control, and promote safe food production at the household level. Additionally, it helps lower production costs and supports the concept of sustainable living. The adoption of this technology is considered an important innovation in improving the quality of mushroom cultivation and increasing sustainability in food production.
คณะวิศวกรรมศาสตร์
This study focuses on the use of ceramic tile powder as a cement replacement material in concrete at an appropriate ratio. The objective is to investigate the properties of replacing cement with tile powder and to determine the optimal mixing ratio of tile powder in cement mortar that can yield properties equivalent to or superior to conventional cement mortar. The experiment involved preparing cement mortar samples by replacing cement with two types of ceramic tile powder waste from tile manufacturing plants: waste tile powder and rectified tile powder. The mixing process was divided into two parts: Part 1 used a cement and tile powder ratio, while Part 2 used the results of the strength analysis from Part 1 to adjust the ratio accordingly. Various properties were tested, including specific gravity, normal consistency, setting time, tensile strength, and compressive strength. The results of the study revealed that replacing of cement with rectified tile powder provided the highest tensile and compressive strength, comparable to that of conventional cement mortar. Therefore, the use of ceramic tile powder as a replacement can enhance compressive strength while reducing cement usage, which has positive environmental implications by decreasing greenhouse gas emissions from cement production. Furthermore, this approach promotes the effective use of waste materials from the ceramic industry, contributing to the sustainability of the construction industry.