Aggregatibacter actinomycetemcomitans is a key pathogen in periodontal disease, damaging periodontal ligaments and alveolar bone through biofilm formation. D-LL-31, an engineered antimicrobial peptide, exhibits superior biofilm-killing ability compared to conventional treatments, while DNase I enhances its efficacy by disrupting the biofilm matrix. This study evaluated the combined effects of D-LL-31 and DNase I on A. actinomycetemcomitans biofilms. Results showed that D-LL-31 effectively eradicated biofilms, and its combination with DNase I further enhanced biofilm disruption without cytotoxicity to gingival epithelial cells. The D-LL-31 and DNase I combination shows potential for development as a mouthwash to improve oral health and combat periodontal disease.
โรคปริทันต์เป็นปัญหาสุขภาพช่องปากที่พบบ่อย โดยมี Aggregatibacter actinomycetemcomitans (Aa) เป็นหนึ่งในเชื้อก่อโรคสำคัญ เชื้อชนิดนี้สามารถสร้างไบโอฟิล์ม ซึ่งเป็นกลไกหลักที่ช่วยให้เชื้อดื้อยาต้านจุลชีพและหลบเลี่ยงระบบภูมิคุ้มกัน ทำให้การรักษาด้วยยาปฏิชีวนะทั่วไปไม่ได้ผลอย่างมีประสิทธิภาพ การพัฒนาแนวทางใหม่ในการกำจัดไบโอฟิล์มจึงเป็นสิ่งจำเป็น งานวิจัยนี้มุ่งเน้นศึกษาประสิทธิภาพของ D-LL-31 ซึ่งเป็นเปปไทด์ต้านจุลชีพที่ถูกแปลงทางวิศวกรรม เพื่อทำลายเชื้อที่อยู่ในไบโอฟิล์ม และการใช้ DNase I เพื่อสลายโครงสร้างเมทริกซ์ของไบโอฟิล์มร่วมกัน ซึ่งอาจเป็นแนวทางใหม่ในการพัฒนา น้ำยาบ้วนปาก ที่ช่วยลดเชื้อก่อโรคในช่องปากและป้องกันโรคปริทันต์ได้อย่างมีประสิทธิภาพ
คณะวิศวกรรมศาสตร์
The presented project topic is Garbage Sorting Systems. The purpose is to study the operation and develop a waste sorting system that can automatically detect the type of waste using a proximity sensor to separate the types of metal and non-metal waste, as well as an ultrasonic sensor to check the amount of waste in the bin. If the amount of waste exceeds the specified amount, the system will send a notification to the communication device connected to the system, such as a smartphone or computer. The operation of the system is designed to increase the efficiency of waste management, reduce the burden of manual waste sorting, and promote recycling. This system can be applied in various places, such as educational institutions or public places, to help reduce the amount of waste that is not properly separated and increase the opportunity to reuse waste.
คณะวิศวกรรมศาสตร์
Nowadays, consumers may have experienced situations where they don't know which product to use based on their skin problems, the product they use doesn't give the desired results, the product is not worth the price, allergic to certain chemicals in the product ,or use multiple products and have ingredients that should not be used together leading to irritation. For this reason, we develop an application to analyze skin care product ingredients to solve such problems. This allows consumers to correctly understand information about the ingredients in products and know which products they should use according to their skin problems without having to rely on chemical knowledge and get products that are the best value for money. The project has integrated software knowledge to develop an application for analyzing skin care product ingredients. To find and recommend suitable skin care products to consumers. The information on various important ingredients has been collected from reliable articles and research.
คณะวิทยาศาสตร์
Eco Grow Pellets are high-porosity plant-growing clay pellets made from ceramic industrial sediment, blended with ground chicken bone to enhance calcium and essential minerals, promoting strong and healthy plant growth. They are suitable for all types of plants, especially those requiring well-aerated soil with good water drainage. Eco Grow Pellets are an innovative clay-based growing medium designed to optimize plant cultivation efficiency. Their high porosity structure allows for excellent air and water circulation, reducing soil compaction and waterlogging—common causes of root rot and stunted growth. Additionally, the pellets are enriched with calcium and essential minerals from ground chicken bones, reinforcing plant structure and enhancing root strength, enabling better nutrient absorption. This product is made from 100% recycled ceramic industrial sediment, aligning with the principles of Zero Waste and the BCG Economy Model. It helps minimize industrial waste while transforming discarded materials into high-value, eco-friendly growing media. Eco Grow Pellets are ideal for vegetables, flowers, and potted plants, offering ease of use, cleanliness, and safety. They contribute to sustainable agriculture by improving both crop productivity and environmental health.