Innovation Owner
นาย Saharut Wongkaewkhiaw
Advisor
Details
This study evaluates the combination of D-LL-31 and DNase I to eradicate biofilms of the periodontal pathogen Aggregatibacter actinomycetemcomitans. The findings demonstrate potential for developing a safe and effective mouthwash solution.
Aggregatibacter actinomycetemcomitans is a key pathogen in periodontal disease, damaging periodontal ligaments and alveolar bone through biofilm formation.
- D-LL-31: An engineered antimicrobial peptide that exhibits superior biofilm-killing ability compared to conventional treatments.
- DNase I: Enhances efficacy by disrupting the biofilm matrix.
Results showed that D-LL-31 effectively eradicated biofilms, and its combination with DNase I further enhanced biofilm disruption without cytotoxicity to gingival epithelial cells. This combination shows potential for development as a mouthwash to improve oral health and combat periodontal disease.
Objective
The objectives are to investigate the efficacy of D-LL-31 combined with DNase I against A. actinomycetemcomitans biofilms and to assess the cytotoxicity of D-LL-31 on gingival epithelial cells.
- To study the efficacy of D-LL-31 combined with DNase I against A. actinomycetemcomitans biofilms.
- To study the cytotoxicity of D-LL-31 on gingival epithelial cells.