In a world increasingly focused on sustainability and reducing environmental impact, DreamHigh is pioneering an innovative approach to packaging solutions using mycelium—a natural, biodegradable, and renewable material derived from fungi. Our mission is to revolutionize the packaging industry by offering eco-friendly alternatives that not only reduce waste but also align with global efforts to combat climate change. Mycelium packaging offers a compelling alternative to traditional plastic and Styrofoam packaging, which contribute significantly to environmental pollution. It is fully biodegradable, compostable, and capable of breaking down in natural environments within weeks, leaving no toxic residues behind. Additionally, mycelium-based products are lightweight, durable, and customizable, making them suitable for a wide range of applications, from consumer goods packaging to protective shipping materials. DreamHigh’s business plan outlines a scalable production process leveraging advanced mycelium cultivation techniques and partnerships with local agricultural sectors to utilize agricultural waste as a key raw material. This not only ensures cost-efficiency but also supports a circular economy by repurposing waste that would otherwise be discarded.
เนื่องจากเราเล็งเห็นถึงปัญหาของการทิ้งโฟมหรือพลาสติกกันกระแทก ที่ใช้เวลาในการย่อยสลายนาน เราจึงนำตัวไมซีเลียมที่ใช้เวลาย่อยสลายไม่นานอีกทั้งยังเป็นมิตรต่อธรรมชาติ
วิทยาลัยเทคโนโลยีและนวัตกรรมวัสดุ
The development of skin-on-a-chip models plays a crucial role in research for drug and cosmetic development. Traditional approaches often utilize two-dimensional (2D) methods that rely on culturing cells on flat surfaces, resulting in a lack of complexity in skin structure and realistic cell interactions. Moreover, traditional methods have limitations in mimicking fluid flow and nutrient circulation, which affects the accuracy of pharmaceutical testing and the prediction of drug effects. This has led to the advancement of three-dimensional (3D) skin models using new microfluidic technology, enhancing the realism of skin structure by replicating both the epidermis and dermis layers, as well as simulating fluid flow similar to physiological conditions in the human body. The design of 3D systems allows for more realistic cell arrangement and interactions, enabling better simulation of skin functions and increasing the accuracy in evaluating the effects of various substances on cell responses, including absorption, inflammation, and wound healing. Therefore, the development of three-dimensional (3D) skin models not only addresses the limitations of traditional methods but also represents a significant step forward in creating models that can be effectively applied in drug testing and pharmaceutical product development.
คณะเทคโนโลยีการเกษตร
This project presents a design and management approach for agricultural land in Kanchanaburi Province. The case study area is situated in Wangdong Subdistrict, Mueang Kanchanaburi District, covering an area of approximately 18 rai (7.2 acres). As the user seeks a simplified lifestyle in the countryside, surrounded by nature, the design aligns with this vision of simplicity and sustainability. The land is systematically allocated to optimize the benefits for both daily living and agricultural industry development. The crop cultivation zones are designed to suit the local climate and plant varieties, ensuring high-quality yields for continuous utilization. Meanwhile, the livestock zones are clearly delineated to maintain balance and organization. This approach not only ensures food security and income generation but also promotes a lifestyle that harmonizes with nature, minimizes environmental impact, and supports the long-term development of an efficient and eco-friendly agricultural industry. Comprehensive attention is given to the positioning of various zones, considering wind direction and sunlight exposure. Additionally, the design undergoes a rigorous drafting and review process to ensure the optimal outcomes for the land's utilization.
คณะทันตแพทยศาสตร์
Objective or Background: Dental caries is still one of the most significant dental problems worldwide, with prevalence rates up to 90% among children and adults. Cariogenic bacteria, especially Streptococcus mutans, is the primary microorganism involved in the pathogenesis through carbohydrate metabolism and biofilm formation, which are challenging to eradicate. Histatin-5 (HST-5), a human salivary antimicrobial peptide, has demonstrated antimicrobial activity against various fungal and bacterial pathogens. Phytosphingosine (PHS), an endogenous bioactive sphingolipid found in fungi, plants, and humans, also shows antimicrobial properties. This study aimed to evaluate the killing activity of HST-5 alone and in combination with PHS against S. mutans under biofilm-stimulating conditions. Materials and Methods: Antimicrobial activity against a planktonic culture of S. mutans was evaluated using a time-kill assay, and biofilm-forming capacity was confirmed by crystal violet staining assay. The killing ability against 24h pre-formed biofilm was determined using Transferable Solid Phase (TSP) pin lid model. Synergistic activity between HST-5 and PHS was evaluated using the checkerboard technique. Additionally, the cytotoxicity of the tested agent on human gingival fibroblast cells (hGFs) was assessed after 1 h of incubation using an MTT assay. Results: A time-kill assay revealed that both HST-5 and PHS exhibit time- and concentration-dependent activity against the planktonic form of S. mutans. PHS achieved over 90% killing activity within 15 min at 5 μg/ml, whereas HST-5 required 30 min to reach 90% killing at 20 μM. The biofilm formation capacity of S. mutans was confirmed. The inhibitory concentrations (IC50) of HST-5 and PHS against S. mutans biofilm were 25 μM and 13.5 μg/ml, respectively. A synergistic interaction between HST-5 and PHS, with IC50 values reduced by 8-fold and 16-fold, respectively. No cytotoxic effects were observed in hGFs cells at the concentration of the synergistic interaction. Conclusions: Therefore, the combination of HST-5 and PHS may enhance the effectiveness of anti-infective agents against S. mutans biofilm, potentially preventing the development of dental caries.