In a world increasingly focused on sustainability and reducing environmental impact, DreamHigh is pioneering an innovative approach to packaging solutions using mycelium—a natural, biodegradable, and renewable material derived from fungi. Our mission is to revolutionize the packaging industry by offering eco-friendly alternatives that not only reduce waste but also align with global efforts to combat climate change. Mycelium packaging offers a compelling alternative to traditional plastic and Styrofoam packaging, which contribute significantly to environmental pollution. It is fully biodegradable, compostable, and capable of breaking down in natural environments within weeks, leaving no toxic residues behind. Additionally, mycelium-based products are lightweight, durable, and customizable, making them suitable for a wide range of applications, from consumer goods packaging to protective shipping materials. DreamHigh’s business plan outlines a scalable production process leveraging advanced mycelium cultivation techniques and partnerships with local agricultural sectors to utilize agricultural waste as a key raw material. This not only ensures cost-efficiency but also supports a circular economy by repurposing waste that would otherwise be discarded.
เนื่องจากเราเล็งเห็นถึงปัญหาของการทิ้งโฟมหรือพลาสติกกันกระแทก ที่ใช้เวลาในการย่อยสลายนาน เราจึงนำตัวไมซีเลียมที่ใช้เวลาย่อยสลายไม่นานอีกทั้งยังเป็นมิตรต่อธรรมชาติ
คณะวิศวกรรมศาสตร์
ยานยนต์ไฟฟ้าดัดแปลง
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
คณะวิศวกรรมศาสตร์
The designing of mosquitoes counting system instrument is presented in this work. The mosquitoes that were counted died in order not to measure duplicate counting data. As soon as the input source counting machine can detect the mosquito, the single trigger signal is transmitted to the IOT system to interrupt the server immediately. The number of real mosquito is not transmitting to the IOT but only a signal to interrupt the server. The server records the number of the interrupt signal with real-time clock. Then the interrupt information will be further handled. The front end counting machine consist of the high voltage generate with the suitable voltage value and electrode distance for the required mosquitoes size. The low trigger pulse signals of the mosquitoes killed by high voltage are sending to the controller unit. Immediately, interrupt counting signal of the number of mosquitoes is sent to the big stream data collection on IOT system by the time stamp technique. Form the measurement results, 10 live sample mosquitoes in a limited space box to fly though the counting machine show that the count results are 100% correct count.