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Development of alginate hydrogel/carrageenan/gellan gum based composited material and their application as oral delivery carriers.

Abstract

This study aims to develop alginate-based hydrogels reinforced with carrageenan and gellan gum as composite materials for oral drug delivery. Alginate, a naturally derived polymer from brown algae, forms a gel upon exposure to cations such as calcium ions, enhancing the hydrogel’s structural integrity. Carrageenan and gellan gum, both polysaccharides, further improve stability and encapsulation efficiency. This research investigates the physical properties, mechanical strength, encapsulation capacity, and swelling behavior of hydrogel beads under simulated gastrointestinal conditions. The findings are expected to demonstrate that incorporating carrageenan and gellan gum enhances the durability and stability of hydrogel beads while enabling controlled release of active compounds in the gastrointestinal tract. These advanced hydrogel beads hold significant potential for applications in the food and pharmaceutical industries as effective oral delivery systems for bioactive substances.

Objective

ในงานวิจัยนี้มีจุดมุ่งหมายเพื่อพัฒนาไฮโดรเจลบีดส์จากอัลจิเนตที่เสริมด้วยคาร์ราจีแนนและเจลแลนกัม โดยมีคุณสมบัติที่ช่วยเสริมความแข็งแรงและความยืดหยุ่นให้กับโครงสร้างของไฮโดรเจลบีดส์ เพื่อเพิ่มความทนทานและเสถียรภาพมากขึ้น ซึ่งสามารถนำมาใช้ในการห่อหุ้มและปกป้องสารสำคัญ โดยมุ่งเน้นการควบคุมการปลดปล่อยสารสำคัญไปยังจุดเป้าหมาย การศึกษานี้จะครอบคลุมถึงลักษณะทางกายภาพ ความแข็งแรงของไฮโดรเจลบีดส์ และความสามารถในการกักเก็บสารสำคัญ ลักษณะทางกายภาพและการบวม (Swelling) ภายใต้สภาวะจำลองทางเดินอาหาร โดยใช้สารจำลองน้ำย่อยทั้งในกระเพาะอาหารและลำไส้ การพัฒนาไฮโดรเจลบีดส์จากอัลจิเนตที่เสริมด้วยคาร์ราจีแนนและเจลแลนกัมมีศักยภาพในการนำไปใช้งานในอุตสาหกรรมเภสัชกรรมและอาหารที่ต้องการห่อหุ้มสารสำคัญที่มีประสิทธิภาพสูงในอนาคต

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