Coffee is a critical agricultural commodity to be used to produce a premium beverage to serve people worldwide. Coffee microbiome turned to be an essential tool to improve the bean quality through the natural fermentation. Therefore, understanding the microbial diversities could create the final product's better quality. This study investigated the natural microbial consortium during the wet process fermentation of coffee onsite in Thailand to characterize the microorganisms involved in correlation toward the biochemical characteristics and metabolic attributes. Roasting is another important step in developing the complex flavor/ aroma that make coffee to be enjoyable. During the roasting process, the beans undergo many complex and alternatively change in the physicochemical properties from the gained substances in the fermentation process. The changing in the formation of the substances responsible for the sensory qualities, physicochemical/ aroma attributes as well as the health benefits of the final product. Using the starter culture could also develop the distinguished characteristics of coffee (Research collaboration with Van Hart company)
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คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
วิทยาลัยการจัดการนวัตกรรมและอุตสาหกรรม
This research aims to develop a horse treat product that meets the nutritional and health needs of horses by using natural ingredients with beneficial properties, such as oats, wheat flour, corn flour, and organic molasses. These ingredients are rich in fiber, vitamins, and essential minerals for horses, while also enhancing digestive efficiency, reducing the risk of colic, and providing an appropriate energy source. The treat is designed with a shape suitable for a horse’s chewing behavior and is infused with Thai fruit flavors, such as pineapple and ripe mango, to attract horses and make consumption easier. The production process emphasizes cleanliness and safety by selecting organic ingredients and avoiding harmful preservatives. The packaging is designed to maintain product quality for an extended period, prevent moisture, and be convenient for horse owners to use. Additionally, the treat can be used as a reward during horse training, helping to strengthen the bond between the horse and its owner while reducing equine stress. This product serves as both a health-boosting snack and an effective training tool, making it suitable for horses that require highly nutritious supplements. It also provides a new option for horse owners seeking a safe and beneficial product for their horse’s overall well-being.
คณะวิศวกรรมศาสตร์
This Project has been undertaken to address the need for skill development and knowledge enhancement in pneumatic systems and automation control, which are crucial in today’s manufacturing industry. Pneumatic systems play a vital role in various production processes, including machine control, automated devices, and assembly lines. However, the Department of Measurement and Control Engineering currently lacks a laboratory dedicated to the study and experimentation of pneumatic systems due to the deterioration and lack of maintenance of the previously used equipment. This has resulted in students missing the opportunity to practice essential skills required in the industrial sector. The authors of this thesis recognize the necessity of reviving and developing a pneumatic laboratory that can effectively support teaching, learning, and research activities. This project focuses on studying and developing industrial robotic arm control systems and pneumatic systems, integrating modern technologies such as Programmable Logic Controllers (PLC) and AI Vision. These systems are intended to be applicable to real-world industrial contexts. The outcomes of this project are expected to not only enhance the understanding of relevant technologies but also aim to transform the laboratory into a vital learning hub for current and future students. Furthermore, this initiative seeks to improve the competitiveness of students in the job market and support the development of innovations in the manufacturing industry in the years to come.