This project aims to propose a design for a red offal processing room in a pork processing plant that processes 500 pigs per day or 80 pigs per hour. Each pig weighs approximately 105 kilograms, with 3.47% of the weight consisting of red offal. The process involves separating liver, gall bladder, heart, lungs, spleen, and kidneys as required. These parts are then chilled in cold water to reduce their temperature to below 7°C before packaging and sealing. Sorting is based on the number of pieces and weight, depending on the type of product. The processing times of sorting chilling and packaging vary depending on the product's type and size. The design was developed using data collected from the current production line and referenced standards. The room layout was planned using Systematic Layout Planning (SLP) principles to analyze activity relationships within the room and define functional areas. Equipment sizes and the required number of operators were calculated to ensure optimal use of space. The red offal processing room was designed with an area of 56 square meters. After the layout design was completed, a 3D model was created using SketchUp 2024, and the workflow and operations were simulated and analyzed using Flexsim 2024
บริษัท เบทาโกร จำกัด (มหาชน) ได้มีแผนการขยายโรงงานแปรรูปสุกรทั้งในประเทศและต่างประเทศ การออกแบบกระบวนการผลิตจึงเป็นสิ่งสำคัญที่ทำให้โรงงานที่จะก่อตั้งนั้นสามารถใช้งานได้อย่างมีประสิทธิภาพทั้งในด้านกระบวนการการผลิตและความสะอาด เพื่อทำให้สินค้าที่ส่งมอบแก่ผู้บริโภคมีคุณภาพที่ดี โดยผลิตภัณฑ์ที่สำคัญของโรงงานแปรรูปสุกร ได้แก่ กลุ่มชิ้นส่วนสุกรตัดแต่ง และกลุ่มเครื่องในสุกร ซึ่งประกอบไปด้วยเครื่องในแดง และเครื่องในขาว โครงงานนี้ได้รับมอบหมายให้ศึกษากระบวนการทำงานเพื่อออกแบบห้องเครื่องในแดงให้รองรับการผลิตที่สูงขึ้นและมีความหลากหลายของผลิตภัณฑ์มากขึ้น โดยกระบวนการทำงานภายในห้องถูกต้องเป็นไปตามหลักการปฏิบัติที่ดีสำหรับโรงแปรรูปสุกรของกรมปศุสัตว์
คณะบริหารธุรกิจ
CO Breathalyzer with Voice Response is the device to measured the level of CO residual in a person's lung who consume tobacco. Measuring residual CO in human breath can identify the tobacco addiction level instead of measuring nicotine in blood.
คณะเทคโนโลยีการเกษตร
This project involves the development of a plant care system for dormitories using IoT (Internet of Things). The system is implemented through programming on an ESP-32 board and controlled via sensors for automated watering. The commands are operated through smartphones, supporting both iOS and Android. It is expected that this project will make plant care in dormitories easier and more convenient.
คณะแพทยศาสตร์
Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.