**Innovative Walking Stick "Buddy Take Care"** The "Buddy Take Care" walking stick is designed to physically support the elderly or individuals recovering from injuries, enabling convenient mobility, reducing the risk of falls, and enhancing walking safety. It is crafted as a keychain-style walking stick with a one-touch open-close mechanism. Building upon existing market products, the Buddy walking stick incorporates additional functionalities such as a portable flashlight, a medicine compartment, and an AirTag slot to maximize utility. Its design prioritizes ease of use, convenience, and safety, specifically tailored for elderly users
ปัจจุบันประเทศไทยได้ก้าวเข้าสู่สังคมผู้สูงอายุอย่างเต็มรูปแบบ ผู้สูงอายุบางกลุ่มประสบปัญหา การเดิน การทรงตัวทำให้มีความเสี่ยงต่อการหกล้ม ซึ่งอาจส่งผลกระทบรุนแรงไม้เท้าจึงเป็นอุปกรณ์ที่ผู้สูงอายุนิยมใช้เพื่อช่วยในการเคลื่อนไหว อย่างไรก็ตาม ไม้เท้าที่พบในท้องตลาดมักมีข้อจำกัด เช่น ขนาดใหญ่ พกพายากเมื่อใช้งานเป็นเวลานานอาจทำให้รู้สึกปวดมือ ทำให้กลุ่มของพวกเราต้องการออกแบบไม้เท้าในรูปแบบใหม่ที่พกพาง่าย และปลอดภัยกับการใช้งานต่อผู้สูงอายุโดยเฉพาะ
คณะเทคโนโลยีการเกษตร
The objective of this experiment was to determine the effect of nitrogen and potassium concentration combination with photoperiod on the growth of Viola in a plant factory to increase the quality of the products, reduce the production time and increase the production cycle throughout the year. The experimental plan was 3x3 Factorial in CRD with nine treatments and three replications (six plants per replication). The factor of this study was two factors; the first factor was three different concentrations of nitrogen and potassium in ratios of 1:1, 1:2 and 2:1. The second factor was the application of different photoperiods. There were 1) 24-hours photoperiod, 2) 8-hours light/16-hours dark photoperiod (Induced flowering state: 13-hours light/11-hours dark photoperiod) and 3) 5-hours light/3-hours dark photoperiod. Controlled temperature at 25 °C, the EC=1.5-2.0 mS/cm and the pH=5.8-6.5 in all treatment. The result showed that the concentration of N: K in the ratio of 1:1 combined with 24-hour photoperiod was the most vegetative growth and also maximizes reproductive growth. The overall great sensory evaluation was an acceptable level and suitable for cooking or decorating dishes. Therefore, the concentration of N: K in the ratio of 1:1 combined with 24-hour photoperiod is the best treatment to increase the quality of the product, reduce the production time of viola flowers in each cycle from 90-100 days down to 43-45 days which is good for farmers.
คณะวิทยาศาสตร์
The aim of experiment was to study the pyrolysis oil derived from sorted landfill plastic waste that had been buried for 15 years by the Nonthaburi Provincial Administrative Organization. The pyrolysis oil was produced using a Fixed-Bed Reactor at 450 °C for 1.5 hours with LPG as the feedstock, with the goal of using the pyrolysis oil as an alternative fuel. The experiment was conducted under four different conditions : (1) plastic waste buried in a landfill that has not been washed but has been reduced in size, (2) plastic waste buried in a landfill that has been washed and has been reduced in size, (3) plastic waste buried in a landfill that not has been washed and has not been reduced in size, (4) plastic waste buried in a landfill that has not been washed and has been reduced size, with activated carbon used as a catalyst. The experiment revealed that three products were produced : Oil, gas, and char in different quantity. The pyrolysis oil were compared in terms of quality based on pH, Heating value, Moisture content, Functional group, and Chemical Composition. The pyrolysis oil we obtained will be referenced according to the criteria from the Department of Energy Business. The analysis results of the pyrolysis can explain which conditions are suitable for replacing fuel oil in industrial It is therefore one of the approaches that helps manage plastic waste in landfills, reducing the quantity by converting it into usable energy.
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.