In this paper, Vanadium dioxide (VO2) thin-film devices with two different use cases have been redesigned to introduce an asymmetrical resonant cavity structure. The structure is designed with the goal of enhancing the optical performance of the central VO2 layer and has an anti-reflection property in the cold state. The advantages and limitations of such a design are discussed.
ปัจจุบันมีงานวิจัยเพื่อออกแบบอุปกรณ์ฟิล์มบางทางแสงเป็นจำนวนมาก เราสามารถใช้คุณสมบัติของวัสดุเปลี่ยนเฟส (PCMs) เพื่อออกแบบอุปกรณ์ที่ทำงานได้สองโหมด อีกทั้งยังมีการออกแบบฟิล์มบางให้มีโครงสร้างเป็นช่องสั่นพ้องเพื่อเพิ่มประสิทธิภาพและปรับย่านการทำงานให้เหมาะสม แต่วิธีการออกแบบช่องสั่นพ้องปกติไม่สามารถใช้ได้กับวัสดุเปลี่ยนเฟส งานวิจัยนี้จะเป็นการเปรียบเทียบวิธีการออกแบบช่องสั่นพ้องที่ไม่สมมาตรเพื่อแก้ปัญหาข้างต้น โดยจะเทียบกับวิธีปกติของอุปกรณ์ฟิล์มบางในงานวิจัยที่มีอยู่ โดยแสดงถึงข้อดีและข้อจำกัดของวิธีการออกแบบใหม่นี้
คณะสถาปัตยกรรม ศิลปะและการออกแบบ
Design a graphic concept for a vending machine and its surrounding area (5x6 meters) featuring INGU skincare products
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
คณะอุตสาหกรรมอาหาร
Plant-based refers to food or products that are primarily made from plants. It can be divided into two categories: one is food that comes entirely from plants and does not include any animal products, and the other is food that contains small amounts of animal products, such as products that contain milk and eggs in limited quantities, which may also be considered part of the definition of plant-based. Plant-based meat products that closely resemble real meat and attract consumers are considered a relatively new innovation. Although tofu, tempeh, and seitan have been around for a long time, recent discoveries have led to the production of plant-based meat products that provide a sensory experience, making it difficult for consumers to distinguish between real meat and plant-based meat. Furthermore, the development of plant-based food products must prioritize quality and safety to maximize consumer benefits. Textured Vegetable Protein (TVP) is a plant-based protein made from soybeans using an extruder. It is used as a primary ingredient in the production of plant-based food products due to several advantages. These include: • High Protein Content: TVP is made from soybeans with the fat extracted, resulting in a high protein content. • Texture: When rehydrated, TVP has a texture that closely resembles meat. • Versatility: TVP has a neutral flavor, allowing it to easily absorb the flavors of various seasonings and sauces. • Cost-Effectiveness: Compared to other protein sources, TVP is relatively inexpensive while providing desirable characteristics. These benefits make TVP an attractive option in the production of plant-based foods. This study focuses on developing TVP into a plant-based crab cake and investigating the shelf life of the product in a tightly sealed container under refrigeration. It also analyzes the hygiene and cleanliness of the production process and how these factors affect the presence or growth of microorganisms that may pose a risk to consumers, referencing the cold food safety standards of Thailand. Finally, recommendations for cleaning operational areas will be provided to establishments as a guideline for developing preliminary food safety procedures in laboratory settings.