The Project Urban House is an initiative focused on developing and designing urban housing solutions that address the growing demand for city living. The project emphasizes efficient space utilization, sustainability, and designs that cater to modern urban lifestyles. Key considerations include the use of eco-friendly materials, the integration of green spaces, and the implementation of smart home technologies to enhance residents' quality of life.
1. พัฒนาทักษะด้านการออกแบบสถาปัตยกรรมภายในสำหรับที่อยู่อาศัยในเมือง 2. ส่งเสริมความคิดสร้างสรรค์และการแก้ปัญหาภายในพื้นที่จำกัด 3. ฝึกการทำงานแบบมืออาชีพและการนำเสนอโครงการ
คณะทันตแพทยศาสตร์
Objective or Background: Dental caries is still one of the most significant dental problems worldwide, with prevalence rates up to 90% among children and adults. Cariogenic bacteria, especially Streptococcus mutans, is the primary microorganism involved in the pathogenesis through carbohydrate metabolism and biofilm formation, which are challenging to eradicate. Histatin-5 (HST-5), a human salivary antimicrobial peptide, has demonstrated antimicrobial activity against various fungal and bacterial pathogens. Phytosphingosine (PHS), an endogenous bioactive sphingolipid found in fungi, plants, and humans, also shows antimicrobial properties. This study aimed to evaluate the killing activity of HST-5 alone and in combination with PHS against S. mutans under biofilm-stimulating conditions. Materials and Methods: Antimicrobial activity against a planktonic culture of S. mutans was evaluated using a time-kill assay, and biofilm-forming capacity was confirmed by crystal violet staining assay. The killing ability against 24h pre-formed biofilm was determined using Transferable Solid Phase (TSP) pin lid model. Synergistic activity between HST-5 and PHS was evaluated using the checkerboard technique. Additionally, the cytotoxicity of the tested agent on human gingival fibroblast cells (hGFs) was assessed after 1 h of incubation using an MTT assay. Results: A time-kill assay revealed that both HST-5 and PHS exhibit time- and concentration-dependent activity against the planktonic form of S. mutans. PHS achieved over 90% killing activity within 15 min at 5 μg/ml, whereas HST-5 required 30 min to reach 90% killing at 20 μM. The biofilm formation capacity of S. mutans was confirmed. The inhibitory concentrations (IC50) of HST-5 and PHS against S. mutans biofilm were 25 μM and 13.5 μg/ml, respectively. A synergistic interaction between HST-5 and PHS, with IC50 values reduced by 8-fold and 16-fold, respectively. No cytotoxic effects were observed in hGFs cells at the concentration of the synergistic interaction. Conclusions: Therefore, the combination of HST-5 and PHS may enhance the effectiveness of anti-infective agents against S. mutans biofilm, potentially preventing the development of dental caries.
คณะเทคโนโลยีการเกษตร
Soil is home to a diverse array of living organisms that interact within a complex food web, facilitating energy and nutrient cycling essential for sustaining life above ground. Among these organisms, soil microbes play a crucial role in supporting plant growth. Beneficial microorganisms enhance nutrient availability, improve soil structure by increasing porosity, and strengthen plant resistance to diseases. Conversely, harmful microorganisms, such as plant pathogens, can hinder plant growth and reduce crop yields when present in high concentrations. Neutral microorganisms, which naturally inhabit the soil, contribute to the soil ecosystem without directly impacting plants. A single teaspoon of soil contains over a billion microorganisms, yet only about 1% of them can be cultured in laboratory conditions. This highlights soil as one of the richest reservoirs of microbial diversity on Earth.
คณะวิทยาศาสตร์
Agricultural products and by-products are important raw materials in various industries including cosmetics and pharmaceuticals. Agro-based fibers have the composition, properties and structure that make them suitable for uses as composite-cosmetic industry. Upon microwave digestion, cellulose have been successfully synthesized into nanocrystalline cellulose (NCC) with lengths from 50-1000 nm, widths between 5-70 nm. Nanocrystalline cellulose was grafted with cosmetic active ingredients such as glycerin), sodium hyaluronate), glycolic acid, and nicotinamide. The beauty active ingredients attached nanocelluloses can penetrate through the skin to enhance beauty and youth.