This book introduces basic management concepts that are applicable to technological innovation development. It encompasses various tech settings like Agro & Health tech, in addition to the more commonly referred digital sector.
องค์ความรู้ด้านการจัดการธุรกิจเทคโนโลยี ถือเป็นเรื่องใหม่ ยังไม่เป็นที่รู้จักในวงกว้าง เมื่อเปรียบเทียบกับ สาขาอื่นๆ เช่น การตลาด หรือ การจัดการทรัพยากรมนุษย์ เป็นต้น
คณะแพทยศาสตร์
Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.
คณะเทคโนโลยีการเกษตร
In the present day, interest in health and the consumption of chemical-free food has been steadily increasing, particularly in homegrown produce such as Phoenix oyster mushrooms (Pleurotus pulmonarius), which are highly nutritious and suitable for weight control. However, small-scale mushroom cultivation often faces challenges related to unsuitable environmental conditions, such as unstable temperature and humidity, which affect the growth and quality of the mushrooms. The development of an automatic temperature and humidity control system plays a crucial role in addressing these issues by utilizing sensor technology to monitor and adjust environmental conditions with precision. This helps enhance production efficiency, reduce human errors in manual control, and promote safe food production at the household level. Additionally, it helps lower production costs and supports the concept of sustainable living. The adoption of this technology is considered an important innovation in improving the quality of mushroom cultivation and increasing sustainability in food production.
คณะวิศวกรรมศาสตร์
This project presents an interactive kiosk system designed to facilitate students, staff, and visitors within the university campus. The kiosk provides real-time event updates, news, and university document access via QR codes or email. It integrates a 3D map of the engineering department with navigation assistance, allowing users to locate offices and other facilities efficiently. Additionally, it features a room booking system, enabling users to reserve spaces through an online platform and check in via QR code scanning at the kiosk. By integrating digital technology and smart urban solutions, this system enhances accessibility, campus management, and visitor experience.