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KMITL Expo 2026
Limno
Acne
Gel:
Limnophila
aromatica
Gel
–
Disrupting
the
Acne
Cycle
with
the
Power
of
Nature
คณะวิทยาศาสตร์
AI Translated
Limno Acne Gel: Limnophila aromatica Gel – Disrupting the Acne Cycle with the Power of Nature

Innovation Owner

TM

thanaporn maswanna

Advisor

Details

This study developed an anti-acne gel using partially purified Limnophila aromatica extract, demonstrating potent antibacterial activity against Cutibacterium acnes. The formulation is stable, safe for human skin, and free from parabens, silicones, and synthetic fragrances.

This study aimed to develop an anti-acne gel formulation using partially purified Limnophila aromatica extract and to evaluate its antibacterial efficacy, stability, and safety in accordance with international standards.

  • Efficacy: The extract exhibited potent inhibitory and bactericidal activities against Cutibacterium acnes (MIC/MBC = 14.26 µg/mL), performing twice as effectively as Centella asiatica extract.
  • Selectivity: The gel selectively inhibited C. acnes without disrupting the normal skin microbiota, Staphylococcus epidermidis.
  • Stability: Accelerated stability testing (40 °C and 50 °C for 3 months) revealed excellent formulation stability with no phase separation, a stable pH of 5.9–6.1, and a predicted shelf life of 1 year.
  • Safety: The product met international standards (FDA BAM, ISO, USP), showed no cytotoxicity toward human HaCaT keratinocytes, and induced no skin irritation in a human volunteer panel.
  • Commercial Readiness: Free from parabens, silicones, and synthetic fragrances, this formulation is fully prepared for technology transfer and commercialization in the cosmeceutical industry.

Objective

The objectives are to develop a ready-to-use acne gel formulation using partially purified Limnophila aromatica extract, evaluate its antibacterial efficacy, and study the product's stability.

  1. To develop an anti-acne gel formulation using partially purified Limnophila aromatica extract in a ready-to-use tube format.
  2. To evaluate the antibacterial efficacy of the formulation.
  3. To study the stability of the Limnophila aromatica acne gel product.

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